{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T05:24:12Z","timestamp":1791869052816,"version":"4.3.4"},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2003,6,16]],"date-time":"2003-06-16T00:00:00Z","timestamp":1055721600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2003,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>The goal of the current study was to clarify treatment outcomes for adult patients with rhabdomyosarcoma (RMS). Published series have reported definitively worse results for adults with RMS compared with children with RMS. This finding casts doubt on whether RMS is the same disease in adults as it is in children.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>Of 190 patients with RMS who were age 18 years or older and whose cases were recorded over a 25\u2010year span in the pathology database of the Istituto Nazionale Tumori (Milan, Italy), 171 could be analyzed retrospectively for treatment outcome. The authors attempted to stratify patients according to the degree to which they had been treated appropriately, based on current treatment guidelines for childhood RMS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>The overall rate of response to chemotherapy was 85%. For the entire series, 5\u2010year event\u2010free survival and 5\u2010year overall survival (OS) were 28% and 40%, respectively. Among the 110 patients with embryonal, alveolar, or \u2018not otherwise specified\u2019 RMS, 5\u2010year OS was 46%; however, 5\u2010year OS was 61% for patients within this group (39% of the total) who had high scores for appropriate treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>The current series parallels other published series in that it confirms the finding of a relatively poor long\u2010term outcome for adult patients with RMS. However, for patients whose treatment adhered to the current guidelines for treatment of children, outcome was similar to what has been reported in pediatric series. In addition, the rate of response to chemotherapy for the entire series was similar to the rate typically observed among children. These findings suggest that adults and children with RMS should receive similar treatment. Treatment protocols adopted from pediatric programs but tailored to adults could increase adults' chances of receiving appropriate treatment; prospective studies are needed to test this idea. Cancer 2003;98:571\u201380. \u00a9 2003 American Cancer Society.<\/jats:p>\n                    <jats:p>DOI 10.1002\/cncr.11550<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncr.11550","type":"journal-article","created":{"date-parts":[[2003,7,21]],"date-time":"2003-07-21T06:11:12Z","timestamp":1058767872000},"page":"571-580","source":"Crossref","is-referenced-by-count":340,"title":["Rhabdomyosarcoma in 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