{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T11:52:42Z","timestamp":1792842762557,"version":"4.5.0"},"reference-count":10,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2003,8,21]],"date-time":"2003-08-21T00:00:00Z","timestamp":1061424000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2003,10,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Photodynamic therapy (PDT) currently is approved for the palliative treatment of malignancies of the aerodigestive tract using laser\u2010activated porfimer sodium. A new approach has been developed, based on intratumoral placement of a nonlaser light device that activates talaporfin sodium, that may expand the use of PDT to include a broader range of treatment\u2010resistant malignancies. The safety of this approach was assessed in a Phase I study in patients with locally advanced, refractory tumors.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Twenty\u2010one patients with radiation\u2010resistant or chemotherapy\u2010resistant or inoperable malignancies were enrolled in four cohorts representing four light doses. Patients were treated with a single intratumoral light device and a fixed photosensitizer dose. Safety assessments were based on review of adverse events (AEs) and serious adverse events (SAEs), and independent evaluation of computed tomography (CT) images.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>The observed occurrence of treatment\u2010related AEs and SAEs was minimal. No cutaneous phototoxicity was observed in any patient. The overall observed tumor response rate was 33%.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>Photoactivation of talaporfin sodium using intratumoral nonlaser light was found to be safe in the patient population of the current study at all light dose levels tested. Cancer 2003. \u00a9 2003 American Cancer Society.<\/jats:p><jats:p>DOI 10.1002\/cncr.11708<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.11708","type":"journal-article","created":{"date-parts":[[2003,10,6]],"date-time":"2003-10-06T03:02:34Z","timestamp":1065409354000},"page":"1767-1771","source":"Crossref","is-referenced-by-count":59,"title":["A multicenter Phase I safety study of intratumoral photoactivation of talaporfin sodium in patients with refractory solid tumors"],"prefix":"10.1002","volume":"98","author":[{"given":"Robert A.","family":"Lustig","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas J.","family":"Vogl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Fromm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa","family":"Cuenca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Alex Hsi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anil K.","family":"D'Cruz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zdenko","family":"Krajina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marko","family":"Turi\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anil","family":"Singhal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James C.","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2003,8,21]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"2326","article-title":"Identification of singlet oxygen as the cytotoxic agent in photo\u2010inactivation of a murine tumor","volume":"36","author":"Weishaupt KR","year":"1976","journal-title":"Cancer Res."},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/90.12.889"},{"key":"e_1_2_6_4_2","first-page":"446","volume-title":"Photodynamic therapy and biomedical lasers","author":"Volz W","year":"1992"},{"key":"e_1_2_6_5_2","first-page":"25","article-title":"Cellular aspects of photodynamic therapy for cancer","volume":"10","author":"Mason MD","year":"1999","journal-title":"Rev Contemp Pharmacother."},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000421-198212000-00014"},{"key":"e_1_2_6_7_2","first-page":"139","volume-title":"The science of phototherapy","author":"Grossweiner LI","year":"1994"},{"key":"e_1_2_6_8_2","first-page":"382","article-title":"Detection of PDT\u2010generated singlet oxygen in vivo by near\u2010infrared luminescence","volume":"48","author":"Niedre M","year":"2002","journal-title":"Lasers Surg Med."},{"key":"e_1_2_6_9_2","first-page":"199","article-title":"A Phase I clinical study of photodynamic therapy for early stage lung carcinoma using ME2906 and a diode laser system","volume":"7","author":"Furukawa K","year":"1998","journal-title":"Porphyrins."},{"key":"e_1_2_6_10_2","volume-title":"WHO handbook for reporting results for cancer treatment","year":"1979"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(99)00559-3"}],"container-title":["Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcncr.11708","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cncr.11708","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T16:48:18Z","timestamp":1760287698000},"score":1,"resource":{"primary":{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/10.1002\/cncr.11708"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,8,21]]},"references-count":10,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2003,10,15]]}},"alternative-id":["10.1002\/cncr.11708"],"URL":"https:\/\/doi.org\/10.1002\/cncr.11708","archive":["Portico"],"relation":{},"ISSN":["0008-543X","1097-0142"],"issn-type":[{"value":"0008-543X","type":"print"},{"value":"1097-0142","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,8,21]]}}}