{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T22:15:27Z","timestamp":1790374527444,"version":"4.1.0"},"reference-count":10,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2003,10,14]],"date-time":"2003-10-14T00:00:00Z","timestamp":1066089600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2003,12,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Vulvar carcinoma patients traditionally are offered follow\u2010up after their primary treatment because earlier diagnosis of recurrent disease is believed to improve chances for curative treatment. The objective of the current study was to determine the value of a strict routine follow\u2010up protocol for the detection of recurrences in a large series of patients who were treated for carcinoma of the vulva.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Clinicopathologic data for patients with primary squamous cell carcinoma of the vulva who were treated between January 1990 and July 2000 were prospectively stored in a database. After treatment, patients visited the outpatient clinic at the study institution at gradually increasing intervals. When a recurrence was diagnosed, it was indicated whether the recurrence was local, occurred in the skin bridge, occurred in the inguinal region, or was distant, and this information was registered. Moreover, it was noted whether the diagnosis was made at a routinely scheduled or at an interval follow\u2010up meeting and whether symptoms as noted by the patient herself led to the diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Data from 238 patients with International Federation of Gynecology and Obstetrics (FIGO) Stage I\u2013IV vulvar carcinoma were analyzed with a mean follow\u2010up of 63 months (median, 58 months; range, 6\u2013149 months). Sixty\u2010five of 238 patients (27%) developed recurrent disease; 49 were local recurrences, 2 recurrences were found in the skin bridge, 6 were found in the inguinal region, and 8 were distant recurrences. Forty\u2010two of these 65 recurrences (65%) were detected at a routinely scheduled follow\u2010up meeting, at which time 21 of the 42 patients with recurrent disease (50%) reported symptoms or signs. Local recurrences diagnosed at a routinely scheduled follow\u2010up meeting were found to have a smaller greater dimension (mean, 2.1 cm and median, 1.6 cm; range, 0.3\u20138.0 cm) compared with recurrences detected at an interval meeting (mean, 3.1 cm and median, 3.0 cm; range, 0.4\u20137.0 cm) (<jats:italic>P<\/jats:italic> = 0.04).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>The data from the current study indicated that routinely scheduled follow\u2010up meetings with patients with carcinoma of the vulva result in the detection of smaller recurrences in a substantial proportion of patients compared with self\u2010reported recurrences, without a measurable effect on morbidity or mortality. Cancer 2003;98:2624\u20139. \u00a9 2003 American Cancer Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.11837","type":"journal-article","created":{"date-parts":[[2003,12,8]],"date-time":"2003-12-08T03:02:51Z","timestamp":1070852571000},"page":"2624-2629","source":"Crossref","is-referenced-by-count":52,"title":["The value of routine follow\u2010up in patients treated for carcinoma of the vulva"],"prefix":"10.1002","volume":"98","author":[{"given":"Maaike H. M.","family":"Oonk","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanne A.","family":"de Hullu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harry","family":"Hollema","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marian J. E.","family":"Mourits","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Pras","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anke N. M.","family":"Wymenga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ate G. J.","family":"van der Zee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2003,12,4]]},"reference":[{"key":"e_1_2_5_2_2","first-page":"553","volume-title":"Practical gynecologic oncology","author":"Hacker NF","year":"2000"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(20000701)89:1<116::AID-CNCR16>3.0.CO;2-4"},{"issue":"47","key":"e_1_2_5_4_2","first-page":"2261","article-title":"Follow\u2010up after oncological surgery","volume":"145","author":"Wiggers T","year":"2001","journal-title":"Ned Tijdschr Geneeskd."},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.1994.1282"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.1995.0012"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1996.tb09600.x"},{"key":"e_1_2_5_8_2","first-page":"36","article-title":"Does long\u2010term follow\u2010up have a role for node negative squamous carcinoma of the vulva? The Gateshead experience","volume":"12","author":"Nordin A","year":"2001","journal-title":"Eur J Gynaecol Oncol."},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1996.tb09764.x"},{"key":"e_1_2_5_10_2","first-page":"181","volume-title":"AJCC cancer staging manual","author":"Fleming ID","year":"1997"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.10969"}],"container-title":["Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcncr.11837","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cncr.11837","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T21:20:36Z","timestamp":1760304036000},"score":1,"resource":{"primary":{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/10.1002\/cncr.11837"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,12,4]]},"references-count":10,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2003,12,15]]}},"alternative-id":["10.1002\/cncr.11837"],"URL":"https:\/\/doi.org\/10.1002\/cncr.11837","archive":["Portico"],"relation":{},"ISSN":["0008-543X","1097-0142"],"issn-type":[{"value":"0008-543X","type":"print"},{"value":"1097-0142","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,12,4]]}}}