{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T23:53:18Z","timestamp":1790985198531,"version":"4.1.0"},"reference-count":42,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2003,11,17]],"date-time":"2003-11-17T00:00:00Z","timestamp":1069027200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2004,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>Limited knowledge exists concerning the impact of radical hysterectomy (RH) alone on the sexual function of patients with early\u2010stage cervical carcinoma. The authors investigated the longitudinal course of self\u2010reported sexual function after RH.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>The current study was comprised of 173 patients with lymph node\u2010negative, early\u2010stage cervical carcinoma who had undergone RH and pelvic lymphadenectomy. They were assessed prospectively using a validated self\u2010assessment questionnaire 5 weeks and 3 months, 6 months, 12 months, 18 months, and 24 months after RH. Results were compared with an age\u2010matched control group from the general population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Compared with control women, patients experienced severe orgasmic problems and uncomfortable sexual intercourse due to a reduced vaginal size during the first 6 months after RH, severe dyspareunia during the first 3 months, and sexual dissatisfaction during the 5 weeks after RH. A persistent lack of sexual interest and lubrication were reported throughout the first 2 years after RH. Long\u2010term lack of sexual interest and insufficient vaginal lubrication were confirmed by the patient's self\u2010reported changes 12 months after RH compared with before the cancer diagnosis and by a pre\u2010post comparison within patients. However, most of the patients who were sexually active before their cancer diagnosis were sexually active again 12 months after surgery (91%), although with a decrease in sexual frequency reported.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>RH had a persistent and negative impact on patients' sexual interest and vaginal lubrication whereas the majority of other sexual and vaginal problems disappeared over time. Sexual and vaginal problems in the short\u2010term and long\u2010term after RH should be discussed with the patient before and after surgery. Cancer 2004;100:97\u2013106. \u00a9 2003 American Cancer Society.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncr.11877","type":"journal-article","created":{"date-parts":[[2003,12,18]],"date-time":"2003-12-18T04:01:06Z","timestamp":1071720066000},"page":"97-106","source":"Crossref","is-referenced-by-count":258,"title":["Early\u2010stage cervical carcinoma, radical hysterectomy, and sexual function"],"prefix":"10.1002","volume":"100","author":[{"given":"Pernille T.","family":"Jensen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mogens","family":"Groenvold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne C.","family":"Klee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingrid","family":"Thranov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morten Aa.","family":"Petersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Machin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2003,11,17]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199904153401503"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.1999.5387"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.1997.4849"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003081-200109000-00008"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.2820710407"},{"key":"e_1_2_5_7_2","first-page":"492","article-title":"Complications of radical hysterectomy in women with early stage cervical cancer: clinical analysis of 270 cases","volume":"17","author":"Ayhan A","year":"1991","journal-title":"Eur J Surg Oncol"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02389576"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.2002.6586"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.10155"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19890101)63:1<204::AID-CNCR2820630133>3.0.CO;2-U"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(74)90031-3"},{"key":"e_1_2_5_13_2","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1037\/0022-006X.57.6.683","article-title":"Controlled prospective longitudinal study of women with cancer: I. 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