{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T23:00:46Z","timestamp":1788908446114,"version":"build-2803163510"},"reference-count":34,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2004,2,26]],"date-time":"2004-02-26T00:00:00Z","timestamp":1077753600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2004,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>The frequency of <jats:italic>Strongyloides stercoralis<\/jats:italic> infestation and complication in patients with cancer in the United States is unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>The authors performed a retrospective analysis of <jats:italic>S. stercoralis<\/jats:italic> infection in patients who were undergoing cancer treatment at The University of Texas M. D. Anderson Cancer Center (Houston, TX).<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>The overall <jats:italic>S. stercoralis<\/jats:italic> infection frequency was approximately 1.0 per 10,000 new cancer cases between 1971 and 2003. Twenty\u2010two of 25 patients (88%) were U.S. residents (19 from Texas; 1 each from Mississippi, Tennessee, and Puerto Rico), and the remaining 3 (13%) were from Latin America. Thirteen (52%) had solid\u2010organ malignancies, whereas 12 (48%) had hematologic malignancies (lymphoma or multiple myeloma, <jats:italic>n<\/jats:italic> = 8; leukemia, <jats:italic>n<\/jats:italic> = 3; aplastic anemia, <jats:italic>n<\/jats:italic> = 1). Twelve patients (48%) received systemic corticosteroids, 9 (36%) received antineoplastic therapy, and 2 underwent hematopoietic stem cell transplantation (HSCT). Diarrhea was reported in 13 patients (57%), and eosinophilia was observed in 11 patients (48%); 4 patients (16%) had probable hyperinfection syndrome (in 3 cases of polymicrobial gram\u2010negative bacteremia, 1 patient had <jats:italic>Klebsiella pneumoniae<\/jats:italic> pneumonia, whereas 1 patient presented with <jats:italic>K. pneumoniae<\/jats:italic> lung infection alone). Evidence of definite pulmonary hyperinfection syndrome was observed in 2 HSCT recipients (8%). Fourteen (74%) of 19 patients responded to thiabendazole therapy. Two patients with definite pulmonary hyperinfection syndrome developed fatal <jats:italic>S. stercoralis<\/jats:italic> hemorrhagic alveolitis despite receiving high\u2010dose thiabendazole plus ivermectin therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>In the current study, strongyloidiasis was uncommon in patients with cancer and remained localized in individuals with solid\u2010organ malignancies. Definite pulmonary accelerated autoinfections were observed only in HSCT recipients. Therefore, pre\u2010HSCT <jats:italic>S. stercoralis<\/jats:italic> screening in individuals from endemic regions of the United States warrants further study. Cancer 2004;100:1531\u20136. \u00a9 2004 American Cancer Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.20120","type":"journal-article","created":{"date-parts":[[2004,3,23]],"date-time":"2004-03-23T08:40:57Z","timestamp":1080031257000},"page":"1531-1536","source":"Crossref","is-referenced-by-count":68,"title":["Strongyloidiasis in patients at a comprehensive cancer center in the United States"],"prefix":"10.1002","volume":"100","author":[{"given":"Amar","family":"Safdar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kumthorn","family":"Malathum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saul J.","family":"Rodriguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rola","family":"Husni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth V. 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