{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T00:53:26Z","timestamp":1760316806060,"version":"build-2065373602"},"reference-count":29,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2004,4,19]],"date-time":"2004-04-19T00:00:00Z","timestamp":1082332800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2004,5,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Outcome data were analyzed for 27 patients who were affected with recurrent or newly diagnosed high\u2010risk brain tumors and who underwent high\u2010dose chemotherapy with triethylenethiophosphoramide (thiotepa) and etoposide in addition to autologous stem cell transplantation between May 1992 and September 2002.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Fifteen males and 12 females (median age, 11 years) were included in the study. Twelve patients had newly diagnosed high\u2010risk brain tumors, and 15 patients had recurrent brain tumors. The conditioning regimen consisted of thiotepa 900 mg\/m<jats:sup>2<\/jats:sup> and etoposide 1500 mg\/m<jats:sup>2<\/jats:sup> over 3 days starting on Day \u22125. Stem cell rescue was performed using bone marrow (BM) in 8 patients, peripheral blood stem cells (PBSCs) in 18 patients, and BM and PBSCs in 1 patient.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>For the BM group, neutrophil (PMN) engraftment was achieved on Day +14 (median value), whereas platelet (PLT) engraftment was achieved on Day +68 (median value). One patient did not achieve PLT engraftment. For the PBSC group, the PMN engraftment was achieved on Day +10.0 (median value), and the PLT engraftment was achieved on Day +15.5 (median value). Transplantation\u2010related toxicity (evaluated using the Bearman score) included Grade 2\u20133 mucositis in 16 patients, Grade 1 kidney toxicity in 6 patients, Grade 1 liver toxicity in 6 patients, and Grade 2 liver toxicity in 1 patient. Transplantation\u2010related mortality was observed in 1 patient (3.6%), who died of Candida pneumonia. The 3\u2010year overall survival (OS) rate was 44.6%, and the 3\u2010year event\u2010free survival (EFS) rate was 31%. There was a statistically significant difference in OS and EFS rates for patients who underwent ASCT and achieved complete remission compared with patients who had measurable disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>The results of the current study suggest that high\u2010dose chemotherapy followed by ASCT may be beneficial for patients who achieve complete remission before ASCT, whereas for other patients, new strategies are required. Cancer 2004. \u00a9 2004 American Cancer Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.20227","type":"journal-article","created":{"date-parts":[[2004,4,20]],"date-time":"2004-04-20T03:02:26Z","timestamp":1082430146000},"page":"2215-2221","source":"Crossref","is-referenced-by-count":21,"title":["High\u2010dose thiotepa and etoposide in children with poor\u2010prognosis brain 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