{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:30:07Z","timestamp":1789432207252,"version":"build-2803163510"},"reference-count":30,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2004,4,23]],"date-time":"2004-04-23T00:00:00Z","timestamp":1082678400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2004,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>The clinical relevance of mold isolated from blood cultures, even in severely immunosuppressed allogeneic hematopoietic stem cell transplantation (HSCT) recipients, remains uncertain. The authors hypothesized that isolation of non\u2010<jats:italic>Candida<\/jats:italic> fungi from blood cultures in patients undergoing high\u2010risk HSCT would have clinical significance.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>The authors reviewed the records of 73 allogeneic HSCT recipients between January 1, 1993 and January 1, 2001 in whom fungal species were isolated from blood cultures.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Fifty\u2010two episodes of non\u2010<jats:italic>Candida<\/jats:italic> fungemia occurred in 48 patients (66%) after a median of 10 days (range, 2\u2013341) after transplantation. All 48 patients had indwelling intravascular catheters, and 23 patients (48%) had profound neutropenia. Thirty\u2010five of 48 patients had received partially matched, related donor stem cell grafts (19 patients had 3\u2010antigen\u2010mismatched grafts); 35 patients had undergone T\u2010cell depleted transplantation and 9 patients were receiving treatment for acute graft\u2010versus\u2010host disease. In 5 of 48 patients (10%), death was attributed to fungemia that occurred 8\u201311 days after the initial fungal blood culture was obtained; all 5 patients were age &gt; 30 years. No deaths occurred in the younger age group (<jats:italic>n<\/jats:italic> = 22 patients; <jats:italic>P<\/jats:italic> = 0.05). In the 24 patients who did not receive systemic antifungal therapy, 4 deaths (17%) were attributed to infections with <jats:italic>Penicillium<\/jats:italic> (<jats:italic>n<\/jats:italic> = 2 patients), <jats:italic>Epicoccum<\/jats:italic> (<jats:italic>n<\/jats:italic> = 1 patient), or <jats:italic>Penicillium<\/jats:italic> plus <jats:italic>Cladosporium<\/jats:italic> species (<jats:italic>n<\/jats:italic> = 1 patient). Of the 24 patients who received amphotericin B, only 1 patient (4%) died as a result of a probable hematogenous <jats:italic>Aspergillus<\/jats:italic> species infection; this difference in outcome, however, was not significant (<jats:italic>P<\/jats:italic> = 0.2).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>Most of the non\u2010<jats:italic>Candida<\/jats:italic> fungal blood culture isolates in recipients of high\u2010risk, mismatched donor transplantation were clinically nonsignificant. However, because these low\u2010virulence saprophytes occasionally may cause life\u2010threatening disease, a reevaluation of the existing diagnostic paradigm is needed so that clinically significant fungemia may be differentiated from pseudofungemia. Cancer 2004. \u00a9 2004 American Cancer Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.20262","type":"journal-article","created":{"date-parts":[[2004,4,23]],"date-time":"2004-04-23T16:50:43Z","timestamp":1082739043000},"page":"2456-2461","source":"Crossref","is-referenced-by-count":22,"title":["Clinical significance of non\u2010<i>Candida<\/i> fungal blood isolation in patients undergoing high\u2010risk allogeneic hematopoietic stem cell transplantation 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