{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T03:18:37Z","timestamp":1781061517665,"version":"3.54.1"},"reference-count":74,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2004,8,13]],"date-time":"2004-08-13T00:00:00Z","timestamp":1092355200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2004,9,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Subcutaneous panniculitis\u2010like T\u2010cell lymphoma (SPTCL) is an uncommon type of skin lymphoma. The natural history, optimal treatment strategy, and prognostic factors associated with this malignancy are not well defined.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>The authors performed a systematic analysis of all patients with SPTCL reported on in the English\u2010language medical literature, with emphasis on specific clinical features, experiences involving the use of radiotherapy and systemic agents, and prognostic factors predictive of treatment response and clinical outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>One hundred fifty\u2010six patients with SPTCL were identified in the literature. Hemophagocytic syndrome (HPS) was a presenting feature in 37% of patients, and &gt; 90% of patients required treatment at diagnosis. Prednisone was used frequently as initial therapy in patients who had less aggressive disease at presentation; however, durable complete remissions (CR) were infrequent. Anthracycline\u2010based chemotherapy regimens were the most commonly used and most effective systemic treatment options, producing long\u2010term CR in \u223c30% of patients. Among patients who received high\u2010dose chemotherapy and stem cell transplantation (HDT\u2010SCT) for refractory or recurrent disease, 92% achieved CR, with a median response duration of \u2265 14 months. The presence of HPS at diagnosis and expression of the \u03b3\/\u03b4 T\u2010cell receptor (TCR) by tumor cells were associated with poor survival, whereas age was not. After a median follow\u2010up of 24 months, 48% of patients died of disease. The median survival duration was 27 months.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>SPTCL has an aggressive natural history. Nonetheless, a subgroup of patients with SPTCL can have long\u2010term disease remission following anthracycline\u2010based initial therapy or subsequent HDT\u2010SCT. HPS and the TCR phenotype may be useful prognostic markers for patients with this malignancy. 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