{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T02:38:42Z","timestamp":1761100722879,"version":"build-2065373602"},"reference-count":30,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2004,8,13]],"date-time":"2004-08-13T00:00:00Z","timestamp":1092355200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2004,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>To assess the impact of T\u2010cell\/B\u2010cell phenotype on clinical outcome, the authors retrospectively compared patients who had peripheral T\u2010cell lymphoma, unspecified (PTCL\u2010U), with patients who had diffuse large B\u2010cell lymphoma (DLBCL).<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Two hundred ninety\u2010seven cases of PTCL\u2010U and 496 cases of DLBCL that had been transferred from the files of the Intergruppo Italiano Linfomi or the Gruppo Italiano Linfomi were integrated into a unique working file and reviewed by the authors.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>The PTCL\u2010U group and the DLBCL group had significantly different distribution patterns with respect to patient age, gender, disease stage, performance status (PS), the presence or absence of systemic \u201cB\u201d symptoms, the presence or absence of bulky disease, lactic acid dehydrogenase (LDH) levels, and number of extranodal sites (ENS). A significantly greater number of patients in the DLBCL group experienced complete remission (<jats:italic>P<\/jats:italic> &lt; 0.0001). Multinomial logistic regression analysis confirmed that immunophenotype, PS, LDH concentration, and number of ENS were independent predictors of response. At a median follow\u2010up duration of 43 months, there was no observable difference in disease\u2010free survival (DFS) between patients with DLBCL and patients with PTCL\u2010U; however, multivariate analysis did reveal that poorer PS and bone marrow involvement were significantly associated with shorter DFS. Furthermore, although the overall survival (OS) curves associated with the T\u2010cell and B\u2010cell immunophenotypes were significantly different from each other at a median follow\u2010up duration of 37 months (<jats:italic>P<\/jats:italic> = 0.0012), Cox multivariate analysis excluded immunophenotype from the final OS model.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>The findings made in the current study indicate that the natural history of PTCL\u2010U may differ from that of DLBCL. Patients with PTCL\u2010U tended to have less favorable clinical outcomes, although the observed difference in outcome was only partially attributable to immunophenotype, which was independently associated with response, but not with survival. Differences in prognostic factor distributions between patients with PTCL\u2010U and patients with DLBCL may account for some portion of the expected phenotype\u2010associated risk. Cancer 2004. \u00a9 2004 American Cancer Society<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.20531","type":"journal-article","created":{"date-parts":[[2004,8,13]],"date-time":"2004-08-13T18:02:39Z","timestamp":1092420159000},"page":"1601-1608","source":"Crossref","is-referenced-by-count":37,"title":["Clinical relevance of immunophenotype in a retrospective comparative study of 297 peripheral T\u2010cell lymphomas, unspecified, and 496 diffuse large B\u2010cell lymphomas"],"prefix":"10.1002","volume":"101","author":[{"given":"Fortunato","family":"Morabito","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Gallamini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caterina","family":"Stelitano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincenzo","family":"Callea","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cesare","family":"Guglielmi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Santo","family":"Neri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Lazzaro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorella","family":"Orsucci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fiorella","family":"Ilariucci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefano","family":"Sacchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Umberto","family":"Vitolo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimo","family":"Federico","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,9,17]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1984.2.7.788"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.annonc.a057673"},{"key":"e_1_2_5_4_2","doi-asserted-by":"crossref","first-page":"4514","DOI":"10.1182\/blood.V89.12.4514","article-title":"Evaluation of the Revised European\u2010American Lymphoma Classification confirm the clinical relevance of immunophenotype in 560 cases of aggressive non\u2010Hodgkin's lymphoma","volume":"89","author":"Melnyk A","year":"1997","journal-title":"Blood"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V89.11.3909"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-97187-7"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V84.5.1361.1361"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(88)90367-4"},{"volume-title":"Tumours of haematopoietic and lymphoid tissues: pathology and genetics. 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