{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T18:47:58Z","timestamp":1790362078183,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2004,9,23]],"date-time":"2004-09-23T00:00:00Z","timestamp":1095897600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2004,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Pediatric patients with brain tumors (BT) are often excluded from health\u2010related quality of life (HRQOL) studies even though they experience more severe disease and treatment\u2010related sequelae than children with other types of cancer. Parent proxy assessments of HRQOL allow for greater inclusion of children who are developmentally immature, physically ill, or cognitively impaired.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Parents of children ages 2\u201318 years who were diagnosed at Childrens Hospital Los Angeles and Children's Hospital San Diego with BT (<jats:italic>n<\/jats:italic> = 86) or acute lymphoblastic leukemia (ALL; <jats:italic>n<\/jats:italic> = 170) evaluated their children's HRQOL over the previous week using the parent\u2010proxy versions of the Pediatric Quality of Life Inventory (PedsQL\u2122) 4.0 Generic Core scales, the PedsQL\u2122 3.0 Acute Cancer Module, and the PedsQL\u2122 Multidimensional Fatigue scales. Multiple regression analyses were used to determine the independent effect of the child's diagnosis on HRQOL. Separate analyses were conducted for patients receiving treatment, patients who had not received treatment for &lt; 12 months, and patients who had not received treatment for \u2265 12 months.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Patients with BT exhibited more problems than patients with ALL in the physical, social, psychosocial, school, cognitive, and fatigue domains of HRQOL. The Core Physical Health, Core Psychosocial Health, and Fatigue Total scores for patients with BT demonstrated peak improvements for children who had not received treatment for &lt; 12 months and sharp declines for children who had not received treatment for \u2265 12 months. The Core Physical Health and Fatigue Total scores for patients with ALL were highest (better HRQOL) for those who had not received treatment for \u2265 12 months.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>Pediatric patients and survivors of BT experienced more fatigue and HRQOL problems than patients with ALL, and HRQOL differed by treatment status. Cancer 2004. \u00a9 2004 American Cancer Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.20609","type":"journal-article","created":{"date-parts":[[2004,9,23]],"date-time":"2004-09-23T18:00:29Z","timestamp":1095962429000},"page":"2116-2125","source":"Crossref","is-referenced-by-count":216,"title":["Parent proxy\u2013reported health\u2010related quality of life and fatigue in pediatric patients diagnosed with brain tumors and acute lymphoblastic leukemia"],"prefix":"10.1002","volume":"101","author":[{"given":"Kathleen","family":"Meeske","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ernest R.","family":"Katz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie N.","family":"Palmer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tasha","family":"Burwinkle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James W.","family":"Varni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,10,18]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1177\/0094582X9902600601"},{"key":"e_1_2_5_3_2","volume-title":"SEER cancer statistics review, 1975\u20132000","author":"Ries LA","year":"2003"},{"key":"e_1_2_5_4_2","first-page":"51","volume-title":"Cancer incidence and survival among children and adolescents: United States SEER program 1975\u20131995","author":"Gurney JG","year":"1999"},{"key":"e_1_2_5_5_2","first-page":"17","volume-title":"Cancer incidence and survival among children and adolescents: United States SEER program 1975\u20131995","author":"Smith MA","year":"1999"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(20011115)92:10<2709::AID-CNCR1625>3.0.CO;2-D"},{"key":"e_1_2_5_7_2","first-page":"2975","volume-title":"Cancer medicine","author":"Packer RJ","year":"1997"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/jpepsy\/23.5.279"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1367\/1539-4409(2003)003<0329:TPAAPP>2.0.CO;2"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.06.148"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.10428"},{"key":"e_1_2_5_12_2","first-page":"13","article-title":"The Functional Assessment of Cancer Therapy\u2014Anemia (FACT\u2010An) Scale: a new tool for the assessment of outcomes in cancer anemia and fatigue","volume":"34","author":"Cella D","year":"1997","journal-title":"Semin Hematol."},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008842517972"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1024203323830"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005650-200108000-00006"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02310555"},{"key":"e_1_2_5_17_2","volume-title":"Psychometric theory","author":"Nunnally JC","year":"1994"},{"key":"e_1_2_5_18_2","volume-title":"Statistical power analysis for the behavioral sciences","author":"Cohen J","year":"1998"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0148-9062(75)90418-0"},{"key":"e_1_2_5_20_2","volume-title":"Statistical methods in cancer research. 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