{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T21:24:28Z","timestamp":1791321868095,"version":"4.3.1"},"reference-count":104,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2004,9,15]],"date-time":"2004-09-15T00:00:00Z","timestamp":1095206400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2004,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Hematopoietic stem cell transplantation has evolved as a central treatment modality in the management of different hematologic malignancies. Despite adequate posttransplantation immunosuppressive therapy, acute graft\u2010versus\u2010host disease (GVHD) remains a major cause of morbidity and mortality in the hematopoietic stem cell transplantation setting, even in patients who receive human leukemic antigen (HLA) identical sibling grafts. Up to 30% of the recipients of stem cells or bone marrow transplantation from HLA\u2010identical related donors and most patients who receive cells from other sources (matched\u2010unrelated, non\u2010HLA\u2010identical siblings, cord blood) will develop &gt; Grade 2 acute GVHD despite immunosuppressive prophylaxis. Thus, GVHD continues to be a major limitation to successful hematopoietic stem cell transplantation. In this review, the authors summarize the most current knowledge on the pathophysiology, clinical manifestations, and management of this potentially life\u2010threatening transplantation complication. Cancer 2004. \u00a9 2004 American Cancer Society.<\/jats:p>","DOI":"10.1002\/cncr.20613","type":"journal-article","created":{"date-parts":[[2004,9,15]],"date-time":"2004-09-15T14:00:53Z","timestamp":1095256853000},"page":"1936-1946","source":"Crossref","is-referenced-by-count":186,"title":["Acute graft\u2010versus\u2010host disease: Pathophysiology, clinical manifestations, and management"],"prefix":"10.1002","volume":"101","author":[{"given":"Daniel","family":"Couriel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Humberto","family":"Caldera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Champlin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krishna","family":"Komanduri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,10,18]]},"reference":[{"key":"e_1_2_12_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001622-199603000-00002"},{"key":"e_1_2_12_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-472X(00)00677-9"},{"key":"e_1_2_12_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1040-8428(00)00123-2"},{"key":"e_1_2_12_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199310213291703"},{"key":"e_1_2_12_6_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V90.8.3204"},{"key":"e_1_2_12_7_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V95.9.2754.009k25_2754_2759"},{"key":"e_1_2_12_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02983793"},{"key":"e_1_2_12_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199602013340501"},{"key":"e_1_2_12_10_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.136.7.2348"},{"key":"e_1_2_12_11_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.283.5405.1183"},{"key":"e_1_2_12_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0198-8859(02)00758-9"},{"key":"e_1_2_12_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0966-3274(03)00055-8"},{"key":"e_1_2_12_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/5.6.565"},{"key":"e_1_2_12_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199007000-00010"},{"issue":"4","key":"e_1_2_12_16_2","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1182\/blood.V84.4.1320.1320","article-title":"Treatment of acute graft\u2010versus\u2010host disease with humanized anti\u2010Tac: an antibody that binds to the interleukin\u20102 receptor","volume":"84","author":"Anasetti C","year":"1994","journal-title":"Blood."},{"key":"e_1_2_12_17_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V95.1.83"},{"key":"e_1_2_12_18_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V97.9.2886"},{"key":"e_1_2_12_19_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.167.5.2936"},{"key":"e_1_2_12_20_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-03-0909"},{"key":"e_1_2_12_21_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0609.2003.00078.x"},{"key":"e_1_2_12_22_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-07-2109"},{"key":"e_1_2_12_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1083-8791(03)00087-9"},{"key":"e_1_2_12_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1542-3565(04)00011-4"},{"key":"e_1_2_12_25_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V80.12.2964.2964"},{"key":"e_1_2_12_26_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.285.5426.412"},{"key":"e_1_2_12_27_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.169.12.7111"},{"key":"e_1_2_12_28_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.188.12.2199"},{"key":"e_1_2_12_29_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.188.12.2205"},{"key":"e_1_2_12_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature01441"},{"key":"e_1_2_12_31_2","first-page":"2052","article-title":"Infusion of CD4+ donor lymphocytes induces the expansion of CD8+ donor T cells with cytolytic activity directed against recipient hematopoietic cells","volume":"8","author":"Zorn E","year":"2002","journal-title":"Clin Cancer Res."},{"key":"e_1_2_12_32_2","first-page":"825","article-title":"1994 Consensus conference on acute GVHD grading","volume":"15","author":"Przepiorka D","year":"1995","journal-title":"Bone Marrow Transplant."},{"key":"e_1_2_12_33_2","article-title":"High incidence of peri\u2010engraftment fever and rash in Patients after CD8 T cell depleted allogeneic myeloablative peripheral blood stem cell transplantation (PBSCT)","volume":"102","author":"Ho VT","year":"2003","journal-title":"Blood."},{"key":"e_1_2_12_34_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.155.3.1151"},{"key":"e_1_2_12_35_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20020642"},{"key":"e_1_2_12_36_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20020590"},{"key":"e_1_2_12_37_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.194.5.629"},{"key":"e_1_2_12_38_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V99.10.3493"},{"key":"e_1_2_12_39_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm915"},{"key":"e_1_2_12_40_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20020399"},{"key":"e_1_2_12_41_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20020090"},{"key":"e_1_2_12_42_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-06-2085"},{"key":"e_1_2_12_43_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-06-2073"},{"key":"e_1_2_12_44_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198509263131301"},{"key":"e_1_2_12_45_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V80.7.1838.1838"},{"key":"e_1_2_12_46_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199106000-00010"},{"issue":"1","key":"e_1_2_12_47_2","first-page":"49","article-title":"The role of minor histocompatibility antigens in GVHD and rejection: a mini\u2010review","volume":"7","author":"Goulmy E","year":"1991","journal-title":"Bone Marrow Transplant."},{"key":"e_1_2_12_48_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V98.7.2043"},{"key":"e_1_2_12_49_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2001.19.16.3685"},{"key":"e_1_2_12_50_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V94.4.1465"},{"key":"e_1_2_12_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2003.10.006"},{"key":"e_1_2_12_52_2","doi-asserted-by":"publisher","DOI":"10.1080\/1042819031000119226"},{"key":"e_1_2_12_53_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-08-2628"},{"key":"e_1_2_12_54_2","first-page":"712a","article-title":"Early acute GVHD: syndrome and clinical implications","volume":"102","author":"Couriel DR","year":"2003","journal-title":"Blood."},{"key":"e_1_2_12_55_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V76.8.1464.1464"},{"key":"e_1_2_12_56_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.med.54.101601.152339"},{"key":"e_1_2_12_57_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2000.03250.x"},{"key":"e_1_2_12_58_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199903150-00007"},{"key":"e_1_2_12_59_2","doi-asserted-by":"publisher","DOI":"10.1089\/152581602753658420"},{"key":"e_1_2_12_60_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-03-0857"},{"key":"e_1_2_12_61_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(03)02098-X"},{"key":"e_1_2_12_62_2","first-page":"712a","article-title":"Graft\u2010versus\u2010host disease of the liver: a clinicopathological analysis","volume":"102","author":"Couriel DR","year":"2003","journal-title":"Blood."},{"key":"e_1_2_12_63_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-09-2748"},{"key":"e_1_2_12_64_2","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2003.1.350"},{"key":"e_1_2_12_65_2","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200262060-00002"},{"key":"e_1_2_12_66_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1701983"},{"key":"e_1_2_12_67_2","first-page":"885","article-title":"FK506 treatment of graft\u2010versus\u2010host disease developing or exacerbating during prophylaxis and therapy with cyclosporin and\/or other immunosuppressants","volume":"15","author":"Kanamaru A","year":"1995","journal-title":"Bone Marrow Transplant."},{"key":"e_1_2_12_68_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1701331"},{"key":"e_1_2_12_69_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1701807"},{"key":"e_1_2_12_70_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1702032"},{"key":"e_1_2_12_71_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1702639"},{"key":"e_1_2_12_72_2","first-page":"2062","article-title":"Phase 3 study comparing methotrexate and tacrolimus with methotrexate and cyclosporine for prophylaxis of acute graft\u2010versus\u2010host disease after marrow transplantation from unrelated donors","volume":"96","author":"Nash RA","year":"2000","journal-title":"Blood."},{"key":"e_1_2_12_73_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1701377"},{"key":"e_1_2_12_74_2","first-page":"2288","article-title":"Early treatment of acute graft\u2010versus\u2010host disease with high\u2010 or low\u2010dose 6\u2010methylprednisolone: a multicenter randomized trial from the Italian Group for Bone Marrow Transplantation","volume":"92","author":"Van Lint MT","year":"1998","journal-title":"Blood."},{"key":"e_1_2_12_75_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1700745"},{"key":"e_1_2_12_76_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199309000-00016"},{"key":"e_1_2_12_77_2","first-page":"77","article-title":"Acute graft\u2010versus\u2010host disease following unrelated donor marrow transplantation: failure of conventional therapy","volume":"10","author":"Roy J","year":"1992","journal-title":"Bone Marrow Transplant."},{"key":"e_1_2_12_78_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V77.8.1821.1821"},{"key":"e_1_2_12_79_2","doi-asserted-by":"publisher","DOI":"10.1053\/bbmt.2002.v8.pm11939605"},{"key":"e_1_2_12_80_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1703032"},{"key":"e_1_2_12_81_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2401687"},{"key":"e_1_2_12_82_2","first-page":"1495","article-title":"Anti\u2010Tac\u2010H, a humanized antibody to the interleukin 2 receptor with new features for immunotherapy in malignant and immune disorders","volume":"50","author":"Junghans RP","year":"1990","journal-title":"Cancer Res."},{"key":"e_1_2_12_83_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.24.10029"},{"key":"e_1_2_12_84_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2001.02582.x"},{"key":"e_1_2_12_85_2","doi-asserted-by":"publisher","DOI":"10.1006\/cyto.1995.0029"},{"key":"e_1_2_12_86_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-200302000-00005"},{"key":"e_1_2_12_87_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-12-4241"},{"key":"e_1_2_12_88_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-01-0267"},{"key":"e_1_2_12_89_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.165.11.6205"},{"key":"e_1_2_12_90_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-01-0028"},{"key":"e_1_2_12_91_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199007000-00001"},{"key":"e_1_2_12_92_2","first-page":"793","article-title":"Specific depletion of alloreactivity against haplotype mismatched related individuals by a recombinant immunotoxin: a new approach to graft\u2010versus\u2010host disease prophylaxis in haploidentical bone marrow transplantation","volume":"17","author":"Mavroudis DA","year":"1996","journal-title":"Bone Marrow Transplant."},{"key":"e_1_2_12_93_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V93.10.3550.410k24_3550_3557"},{"key":"e_1_2_12_94_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2001-12-0353"},{"key":"e_1_2_12_95_2","doi-asserted-by":"publisher","DOI":"10.1080\/146532402320775982"},{"key":"e_1_2_12_96_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0337543100"},{"key":"e_1_2_12_97_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)09413-8"},{"key":"e_1_2_12_98_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-11-3516"},{"key":"e_1_2_12_99_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-04-1098"},{"key":"e_1_2_12_100_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199906033402202"},{"key":"e_1_2_12_101_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1998.00748.x"},{"key":"e_1_2_12_102_2","first-page":"296","article-title":"Clinical\u2010scale selective depletion of alloreactive T cells using an anti\u2010CD25 immunotoxin","volume":"50","author":"Michalek J","year":"2003","journal-title":"Neoplasma."},{"key":"e_1_2_12_103_2","article-title":"Functional assessment and specific depletion of alloreactive human T cells using flow cytometry","author":"Martins SL","journal-title":"Blood."},{"key":"e_1_2_12_104_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-09-3135"},{"key":"e_1_2_12_105_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-08-2987"}],"container-title":["Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcncr.20613","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cncr.20613","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T10:34:31Z","timestamp":1760265271000},"score":1,"resource":{"primary":{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/10.1002\/cncr.20613"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,10,18]]},"references-count":104,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2004,11]]}},"alternative-id":["10.1002\/cncr.20613"],"URL":"https:\/\/doi.org\/10.1002\/cncr.20613","archive":["Portico"],"relation":{},"ISSN":["0008-543X","1097-0142"],"issn-type":[{"value":"0008-543X","type":"print"},{"value":"1097-0142","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,10,18]]}}}