{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:05:31Z","timestamp":1791295531274,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2004,10,8]],"date-time":"2004-10-08T00:00:00Z","timestamp":1097193600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"AOP Orphan Pharmaceutical AG"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2004,11,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>Although the platelet count does not correlate with the rate of thrombosis, there is evidence that a strict control of the platelet count decreases the incidence of thromboembolic complications in essential thrombocythemia. In the current study, the authors evaluated the efficacy and tolerability of anagrelide in thrombocytosis associated with myeloproliferative disorders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      The study cohort comprised 97 patients (\n                      <jats:italic>n<\/jats:italic>\n                      = 69 females,\n                      <jats:italic>n<\/jats:italic>\n                      = 28 males) with a median age of 59 years (range, 21\u201380 years). Patients with essential thrombocythemia (\n                      <jats:italic>n<\/jats:italic>\n                      = 79) or with thrombocytosis due to polycythemia vera (\n                      <jats:italic>n<\/jats:italic>\n                      = 16) or to chronic idiopathic myelofibrosis (\n                      <jats:italic>n<\/jats:italic>\n                      = 2) were enrolled in the multicenter, prospective study. Patients received anagrelide at a starting dose of 0.5 mg twice per day, which was then adjusted for each patient.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Treatment with anagrelide resulted in a rapid decrease in the platelet count, from a median baseline platelet count of 743 \u00d7 10\n                      <jats:sup>9<\/jats:sup>\n                      \/L to a median platelet count of 441 \u00d7 10\n                      <jats:sup>9<\/jats:sup>\n                      \/L after 6 months (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.0001). The proportion of patients with a platelet count &lt; 600 \u00d7 10\n                      <jats:sup>9<\/jats:sup>\n                      \/L increased from 30% at baseline to 77% after the 6\u2010month study period. The rate of major thrombotic complications significantly decreased from 5% to 2% (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.2568). For patients with essential thrombocythemia, the reduction of major thromboembolic complications was significant (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.0455). The rate of minor thromboembolic complications decreased from 25% before anagrelide treatment to 14% during anagrelide treatment (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.0278). No severe side effects were observed during the study period. There was, however, evidence that concomitant administration of acetylsalicylic acid may increase bleeding tendency.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>Anagrelide was an effective and well tolerated treatment modality for reducing platelet counts in both newly diagnosed and pretreated patients with thrombocytosis due to myeloproliferative disorders. Cancer 2004. \u00a9 2004 American Cancer Society.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncr.20646","type":"journal-article","created":{"date-parts":[[2004,10,8]],"date-time":"2004-10-08T13:02:23Z","timestamp":1097240543000},"page":"2239-2246","source":"Crossref","is-referenced-by-count":69,"title":["Anagrelide for thrombocytosis in myeloproliferative disorders"],"prefix":"10.1002","volume":"101","author":[{"given":"Michael","family":"Steurer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guenther","family":"Gastl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wieslaw\u2010Wiktor","family":"Jedrzejczak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Pytlik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Werner","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ernst","family":"Schl\u00f6gl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heinz","family":"Gisslinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,10,8]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1990.8.3.556"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199504273321704"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.3109\/10428199609074373"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-123-9-199511010-00003"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19880315)61:6<1207::AID-CNCR2820610625>3.0.CO;2-4"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830330106"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(89)92142-9"},{"key":"e_1_2_5_9_2","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1182\/blood.V91.2.616","article-title":"Acute myeloid leukemia and myelodysplastic syndromes following essential thrombocythaemia treated with hydroxyurea: high proportion of cases with 17 p depletion","volume":"91","author":"Sterkens Y","year":"1998","journal-title":"Blood."},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1991.tb08118.x"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.1999.tb01110.x"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198805193182002"},{"key":"e_1_2_5_13_2","first-page":"40","article-title":"Effect of anagrelide on platelet count and function in patients with thrombocytosis and myeloproliferative disorders","volume":"77","author":"Balduini CL","year":"1992","journal-title":"Hematologica."},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(92)90017-6"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V97.4.863"},{"key":"e_1_2_5_16_2","first-page":"315","article-title":"Therapy with anagrelide in patients affected by essential thrombocythemia: preliminary results","volume":"77","author":"Mazzucconi MG","year":"1992","journal-title":"Haematologica."},{"key":"e_1_2_5_17_2","first-page":"51","article-title":"Anagrelide for control of thrombocythemia and polycythemia and other myeloproliferative disorders","volume":"34","author":"Petitt RM","year":"1997","journal-title":"Semin Hematol."},{"key":"e_1_2_5_18_2","first-page":"1808","article-title":"Anagrelide zur Kontrolle der myeloproliferativen Thrombozyth\u00e4mie: Langzeiterfahrung bei 6 Patienten (Anagrelide in control of myelopeoliferative thrombocythemia: long\u2010term experiences in 6 patients)","volume":"128","author":"Burkhard R","year":"1998","journal-title":"Schweiz Med Wochenschr."},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.1998.tb01064.x"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-5994.1999.tb01585.x"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1177\/107602960000600307"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.4065\/76.1.22"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1998.00529.x"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002779900136"},{"key":"e_1_2_5_25_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa035572"},{"key":"e_1_2_5_26_2","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.1.3.537"},{"key":"e_1_2_5_27_2","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.1093\/ajhp\/55.19.1979","article-title":"Anagrelide, a selective thrombocytopenic agent","volume":"55","author":"Oertel MD","year":"1998","journal-title":"Am J Health Syst Pharm."},{"key":"e_1_2_5_28_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1999.01234.x"},{"key":"e_1_2_5_29_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1997.d01-2127.x"}],"container-title":["Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcncr.20646","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cncr.20646","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T15:23:15Z","timestamp":1760282595000},"score":1,"resource":{"primary":{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/10.1002\/cncr.20646"}},"subtitle":["A prospective study to assess efficacy and adverse event profile"],"short-title":[],"issued":{"date-parts":[[2004,10,8]]},"references-count":28,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2004,11,15]]}},"alternative-id":["10.1002\/cncr.20646"],"URL":"https:\/\/doi.org\/10.1002\/cncr.20646","archive":["Portico"],"relation":{},"ISSN":["0008-543X","1097-0142"],"issn-type":[{"value":"0008-543X","type":"print"},{"value":"1097-0142","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,10,8]]}}}