{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T09:17:17Z","timestamp":1791883037013,"version":"4.3.4"},"reference-count":40,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2004,10,29]],"date-time":"2004-10-29T00:00:00Z","timestamp":1099008000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2004,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>The authors performed a comprehensive review of the efficacy of fluorodeoxyglucose positron emission tomography (FDG\u2010PET) in the detection of primary tumors in patients with cervical metastases from unknown primary tumors.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Sixteen studies (involving a total of 302 patients) published between 1994 and 2003 were reviewed. These studies evaluated the role of FDG\u2010PET in the detection of unknown primary tumors after conventional workup. In all studies, conventional workup included either panendoscopy or computed tomographic\/magnetic resonance imaging, and in 10 of 16 studies, both of these diagnostic techniques were performed before diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>The overall sensitivity, specificity, and accuracy rates of FDG\u2010PET in detecting unknown primary tumors were 88.3%, 74.9%, and 78.8%, respectively. Furthermore, FDG\u2010PET detected 24.5% of tumors that were not apparent after conventional workup. FDG\u2010PET imaging also led to the detection of previously unrecognized metastases in 27.1% of patients (regional, 15.9%; distant, 11.2%). FDG\u2010PET had notably low specificity and a high false\u2010positive rate (39.3%) in the tonsils. In contrast, the false\u2010positive rates for FDG\u2010PET of the base of tongue and hypopharynx were only 21.4% and 8.3%, respectively. FDG\u2010PET exhibited decreased sensitivity to tumors in the base of tongue (81.5%). The sensitivity of this technique at other sites was 90.5%.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>FDG\u2010PET detected primary tumors that went undetected by other modalities in approximately 25% of cases and was sensitive in the detection of previously unrecognized regional or distant metastases in 27% of cases. FDG\u2010PET had low specificity for tonsillar tumors and low sensitivity for base\u2010of\u2010tongue malignancies. Cancer 2004. \u00a9 2004 American Cancer Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.20687","type":"journal-article","created":{"date-parts":[[2004,11,12]],"date-time":"2004-11-12T19:32:43Z","timestamp":1100287963000},"page":"2641-2649","source":"Crossref","is-referenced-by-count":285,"title":["The role of fluorodeoxyglucose positron emission tomography in cervical lymph node metastases from an unknown primary tumor"],"prefix":"10.1002","volume":"101","author":[{"given":"Kyle E.","family":"Rusthoven","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Koshy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnold 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