{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T17:53:42Z","timestamp":1776362022223,"version":"3.51.2"},"reference-count":41,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2004,11,16]],"date-time":"2004-11-16T00:00:00Z","timestamp":1100563200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2004,12,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Immunocompromised patients have an increased risk of experiencing progression of latent <jats:italic>Mycobacterium tuberculosis<\/jats:italic> infection (LTBI) to active tuberculosis (TB) disease. In January 2002, 2 patients with leukemia (Patients 1 and 2) developed pulmonary TB after recent exposure at 3 hospitals (Hospital A, Hospital B, and Hospital C) and at a residential facility for patients with cancer. Neither was known to have LTBI. Within 1 year, 3 other patients with malignancy and TB disease had been identified at these facilities, prompting an investigation of healthcare facility\u2013associated transmission of <jats:italic>M. tuberculosis<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>The authors performed genotypic analysis of the five available <jats:italic>M. tuberculosis<\/jats:italic> isolates from patients with malignancies at these facilities, reviewed medical records, interviewed individuals who had identical <jats:italic>M. tuberculosis<\/jats:italic> genotypic patterns, and performed tuberculin skin testing (TST) and case finding for possible exposed contacts.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Only Patients 1 and 2 had identical genotypic patterns. Neither patient had baseline TST results available. Patient 1 had clinical evidence of infectiousness 3 months before the diagnosis of TB was ascertained. Among employee contacts of Patient 1, TST conversions occurred in 1 of 59 (2%), 2 of 34 (6%), 2 of 32 (6%), and 0 of 8 who were tested at Hospitals A, B, and C and at the residential facility, respectively. Among the others who were exposed to Patient 1, 1 of 31 (3%), 1 of 30 (3%), 0 of 40 (0%), and 12 of 136 (9%) who were tested had positive TSTs at Hospitals A, B, and C and at the residential facility, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>Delayed TB diagnosis in 2 patients with leukemia resulted in the transmission of <jats:italic>M. tuberculosis<\/jats:italic> to 19 patients and staff at 3 hospitals and a residential facility. Baseline TB screening and earlier clinical recognition of active disease could reduce healthcare facility\u2013associated transmission of <jats:italic>M. tu\u2010berculosis<\/jats:italic> among patients with malignancy. Cancer 2004. Published 2004 by the American Cancer Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.20698","type":"journal-article","created":{"date-parts":[[2004,11,16]],"date-time":"2004-11-16T13:16:27Z","timestamp":1100610987000},"page":"2713-2721","source":"Crossref","is-referenced-by-count":23,"title":["Investigation of healthcare\u2010associated transmission of <i>Mycobacterium tuberculosis<\/i> among patients with malignancies at three hospitals and at a residential facility"],"prefix":"10.1002","volume":"101","author":[{"given":"Joseph L.","family":"Malone","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kashef","family":"Ijaz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lauren","family":"Lambert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louie","family":"Rosencrans","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lynelle","family":"Phillips","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victor","family":"Tomlinson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Arbise","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronald L.","family":"Moolenaar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark S.","family":"Dworkin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo J.","family":"Simoes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,11,16]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.161.4.16141"},{"issue":"6","key":"e_1_2_6_3_2","first-page":"1","article-title":"Targeted tuberculin testing and treatment of latent tuberculosis infection","volume":"49","author":"Centers for Disease Control and Prevention","year":"2000","journal-title":"MMWR Morb Mortal Wkly Rep"},{"issue":"10","key":"e_1_2_6_4_2","first-page":"1","article-title":"Guidelines for preventing opportunistic infections among hematopoietic stem cell transplant recipients","volume":"49","author":"Centers for Disease Control and Prevention","year":"2000","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005382-199701000-00006"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.136.1.67"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197403)33:3<850::AID-CNCR2820330334>3.0.CO;2-H"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/hon.681"},{"key":"e_1_2_6_9_2","first-page":"260","article-title":"Ronald McDonald House\u2014the house that love built","volume":"19","author":"Sanford CC","year":"1993","journal-title":"Pediatr Nurs"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-5394.1998.006003182.x"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0266462301105015"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0936-6555(05)80065-2"},{"issue":"9","key":"e_1_2_6_13_2","first-page":"1","article-title":"Tuberculosis elimination revisited: obstacles, opportunities, and a renewed commitment","volume":"48","author":"Centers for Disease Control and Prevention","year":"1999","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.88.7.1059"},{"issue":"11","key":"e_1_2_6_15_2","first-page":"18","article-title":"Screening for tuberculosis and tuberculosis infection in high\u2010risk populations","volume":"44","author":"Centers for Disease Control and Prevention","year":"1995","journal-title":"MMWR Morb Mortal Wkly Rep"},{"issue":"13","key":"e_1_2_6_16_2","first-page":"1","article-title":"Guidelines for preventing the transmission of Mycobacterium tuberculosis in healthcare facilities","volume":"43","author":"Centers for Disease Control and Prevention","year":"1994","journal-title":"MMWR Morb Mortal Wkly Rep"},{"issue":"10","key":"e_1_2_6_17_2","first-page":"7","article-title":"Prevention and control of tuberculosis in facilities providing long\u2010term care to the elderly. Recommendations of the Advisory Committee for Elimination of Tuberculosis","volume":"39","author":"Centers for Disease Control and Prevention","year":"1990","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"e_1_2_6_18_2","first-page":"869","article-title":"Tuberculosis among residents of shelters for the homeless\u2014Ohio","volume":"40","author":"Centers for Disease Control and Prevention","year":"1990","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1177\/026921639701100607"},{"key":"e_1_2_6_20_2","first-page":"1","article-title":"Essential components of a tuberculosis prevention and control program","volume":"44","author":"Centers for Disease Control and Prevention","year":"1995","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-5231(05)70353-1"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid0811.020402"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid0811.020408"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid0811.020284"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid0811.020424"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid0811.020420"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.158.2.9801062"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/21.2.291"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.31.2.406-409.1993"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid0811.020296"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.35.4.907-914.1997"},{"issue":"11","key":"e_1_2_6_32_2","first-page":"1","article-title":"Treatment of tuberculosis: American Thoracic Society, CDC, and Infectious Diseases Society of America","volume":"52","author":"Centers for Disease Control and Prevention","year":"2003","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"e_1_2_6_33_2","first-page":"217","article-title":"Trends in tuberculosis morbidity\u2014United States","volume":"52","author":"Centers for Disease Control and Prevention","year":"1992","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"e_1_2_6_34_2","doi-asserted-by":"publisher","DOI":"10.1086\/340618"},{"key":"e_1_2_6_35_2","doi-asserted-by":"publisher","DOI":"10.1086\/647073"},{"issue":"2","key":"e_1_2_6_36_2","first-page":"15","article-title":"Guidelines for using the QuantiFERON\u2010TB test for diagnosing latent Mycobacterium tuberculosis infection","volume":"52","author":"Mazurek GH","year":"2003","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"e_1_2_6_37_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2002.06.119"},{"key":"e_1_2_6_38_2","first-page":"255","article-title":"In vivo use of Campath\u20101G to prevent graft\u2010versus\u2010host disease and graft rejection after bone marrow transplantation","volume":"9","author":"Willemze R","year":"1992","journal-title":"Bone Marrow Transplant"},{"key":"e_1_2_6_39_2","doi-asserted-by":"publisher","DOI":"10.1086\/375690"},{"key":"e_1_2_6_40_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa011110"},{"key":"e_1_2_6_41_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.165.7.2107040"},{"key":"e_1_2_6_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-6553(97)90072-9"}],"container-title":["Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcncr.20698","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cncr.20698","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T17:08:55Z","timestamp":1760288935000},"score":1,"resource":{"primary":{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/10.1002\/cncr.20698"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,11,16]]},"references-count":41,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2004,12,15]]}},"alternative-id":["10.1002\/cncr.20698"],"URL":"https:\/\/doi.org\/10.1002\/cncr.20698","archive":["Portico"],"relation":{},"ISSN":["0008-543X","1097-0142"],"issn-type":[{"value":"0008-543X","type":"print"},{"value":"1097-0142","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,11,16]]}}}