{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:00:41Z","timestamp":1761894041787,"version":"build-2065373602"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2004,11,24]],"date-time":"2004-11-24T00:00:00Z","timestamp":1101254400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2005,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Findings of mediastinal uptake of <jats:sup>131<\/jats:sup>I after surgical treatment for differentiated thyroid carcinoma (DTC) are common, especially in young patients. Given the frequency of false\u2010positive findings, a protocol for diagnostic and therapeutic strategies would be useful. With the goal of accurately selecting management strategies, the authors analyzed their data and data found elsewhere in the literature for correlations with the incidence of mediastinal <jats:sup>131<\/jats:sup>I uptake and with treatment for patients exhibiting such <jats:sup>131<\/jats:sup>I uptake.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>All patients with DTC who were treated between 1978 and 2000 at Groningen University Hospital (Groningen, The Netherlands) and who received adjuvant <jats:sup>131<\/jats:sup>I ablation therapy were included in the current analysis, which involved retrospective review of all relevant data.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Five hundred four patients with DTC initially underwent total thyroidectomy, with additional <jats:sup>131<\/jats:sup>I ablation performed for 489 of these patients. In 48 of 489 patients (9.8%), <jats:sup>131<\/jats:sup>I uptake was seen in the mediastinum on a posttreatment scan. Analysis of those 48 patients and of cases in the literature demonstrated that serum thyroglobulin levels, risk status, and the presence of thymus on radiologic images were important in the surgical decision\u2010making process.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>Mediastinal uptake of <jats:sup>131<\/jats:sup>I on posttreatment scans was found in approximately 10% of patients after total thyroidectomy for DTC. Based on the current data and the data presented in the literature, the authors developed a flow chart for determining appropriate treatment strategies, which included mediastinal dissection for high\u2010risk patients and for patients with serum thyroglobulin levels &gt; 10 ng\/mL. Cancer 2005. \u00a9 2004 American Cancer Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.20725","type":"journal-article","created":{"date-parts":[[2004,11,24]],"date-time":"2004-11-24T12:47:02Z","timestamp":1101300422000},"page":"59-67","source":"Crossref","is-referenced-by-count":19,"title":["Implications of mediastinal uptake of <sup>131<\/sup>I with regard to surgery in patients with differentiated thyroid carcinoma"],"prefix":"10.1002","volume":"103","author":[{"given":"Jan Willem","family":"Haveman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ha T. 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