{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T04:16:22Z","timestamp":1791173782658,"version":"4.1.0"},"reference-count":47,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2004,12,1]],"date-time":"2004-12-01T00:00:00Z","timestamp":1101859200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2005,1,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Primary head and neck mucosal melanoma (HNMM) has a poor prognosis with a low local control rate and frequent distant metastases. The objective of the current study was to determine the impact of postoperative radiotherapy on local control and survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>One hundred forty\u2010two patients with primary HNMM treated between 1979 and 1997 were reviewed. Of these, 69 patients with confirmed primary mucosal melanoma, absence of metastatic disease, and definitive management by surgery with or without postoperative radiotherapy and follow\u2010up at the Institut Gustave\u2010Roussy (Villejuif) were selected. The site of primary HNMM was sinonasal in 46 patients, oral in 19 patients, and pharyngolaryngeal in 4 patients. Twenty\u2010two patients (32%) had a locally advanced tumor (T3\u2013T4) and 17 patients had regional lymph node metastases after pathologic examination (pN &gt; 0). Thirty patients underwent surgery alone and 39 received postoperative radiotherapy. Patients with locally advanced tumors had received postoperative radiotherapy more frequently than those with small tumors (<jats:italic>P<\/jats:italic> = 0.02).<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Thirty\u2010seven patients (54%) experienced local disease recurrence and 47 patients (68%) developed distant metastasis. The overall survival rates were 47% at 2 years and 20% at 5 years. In the Cox multivariate analysis, patients with early T\u2010classification tumors who received postoperative radiotherapy had a better local disease\u2010free survival (<jats:italic>P<\/jats:italic> = 0.004 and <jats:italic>P<\/jats:italic> = 0.05, respectively) compared with patients with late T\u2010classification tumors who did not receive postoperative radiotherapy. Patients with advanced T\u2010classification and pN &gt; 0 stage had a shorter distant metastasis disease\u2010free survival compared with patients with early T\u2010classification and pN &lt; 0 stage. Patients with advanced T\u2010classification tumors had a shorter overall survival compared with patients with early T\u2010classification tumors (<jats:italic>P<\/jats:italic> = 0.003).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>The prognosis of patients with HNMM was poor. Patients had a high rate of distant metastasis and a low rate of local control. The current study suggested that postoperative radiotherapy increased local control even for patients with small tumors. Cancer 2005. \u00a9 2004 American Cancer Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.20775","type":"journal-article","created":{"date-parts":[[2004,12,1]],"date-time":"2004-12-01T12:51:58Z","timestamp":1101905518000},"page":"313-319","source":"Crossref","is-referenced-by-count":215,"title":["Postoperative radiotherapy for primary mucosal melanoma of the head and 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