{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T05:11:59Z","timestamp":1767676319062,"version":"build-2065373602"},"reference-count":33,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,1,7]],"date-time":"2005-01-07T00:00:00Z","timestamp":1105056000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2005,2,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>There are conflicting data on the prognostic significance of the number of lymph nodes examined in patients with lymph node\u2010negative breast carcinoma. Therefore, the authors analyzed the impact of the number of tumor\u2010free axillary lymph nodes on disease\u2010free survival (DFS) in two distinct patient populations.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Eight hundred thirty\u2010three consecutive patients with breast carcinoma who underwent mastectomy between 1927 and 1987 and 1094 consecutive patients with breast carcinoma who underwent with breast\u2010conservation therapy between 1984 and 2001 were diagnosed pathologically with negative axillary lymph node status. Patients were stratified into 4 groups according to the number of lymph nodes examined: Group 1 had 1\u20133 lymph nodes examined, Group 2 had 4\u20139 lymph nodes examined, Group 3 had 10\u201320 lymph nodes examined, and Group 4 had &gt; 20 lymph nodes examined.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>In the mastectomy cohort, with a median follow\u2010up of 153 months, the 10\u2010year DFS rate was 70%, 65%, 79%, and 81% for Groups 1\u20134, respectively. On multivariate analysis, pathologic tumor size (<jats:italic>P<\/jats:italic> &lt; 0.001) and the number of lymph nodes examined (<jats:italic>P<\/jats:italic> = 0.010) were significant predictors for long\u2010term DFS. In the breast\u2010conservation cohort, with a median follow\u2010up of 53 months, the 5\u2010year DFS rate was 90%, 91%, 92%, and 95% for Groups 1\u20134, respectively. On multivariate analysis, the only predictors of DFS were method of detection (clinically vs. mammographically) (<jats:italic>P<\/jats:italic> = 0.003) and tumor size (<jats:italic>P<\/jats:italic> = 0.035).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>The recovery of &lt; 10 lymph nodes in lymph node\u2010negative patients who underwent mastectomy resulted in a 10\u201315% decreased long\u2010term DFS rate compared with patients who had a more extensive axillary assessment. However, the number of lymph nodes examined did not have an impact on the DFS rate in a contemporary cohort of patients who underwent breast\u2010conservation therapy, which included radiation. Cancer 2005. \u00a9 2005 American Cancer Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.20830","type":"journal-article","created":{"date-parts":[[2005,1,7]],"date-time":"2005-01-07T18:23:48Z","timestamp":1105122228000},"page":"664-671","source":"Crossref","is-referenced-by-count":28,"title":["Does the number of lymph nodes examined in patients with lymph node\u2010negative breast carcinoma have prognostic significance?"],"prefix":"10.1002","volume":"103","author":[{"given":"Joseph K.","family":"Salama","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruth","family":"Heimann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fen","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neil","family":"Mehta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven 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