{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T01:46:07Z","timestamp":1790905567861,"version":"4.1.0"},"reference-count":46,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2005,3,7]],"date-time":"2005-03-07T00:00:00Z","timestamp":1110153600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2005,4,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) play a role in the processes of extracellular matrix degradation. Changes in their expression levels have been observed in various tumor types, including lung carcinoma. However, their clinical significance and their prognostic importance in the progression of nonsmall cell lung carcinoma (NSCLC) remain to be specified. In this study, mRNA expression levels of MMP\u20101, MMP\u20109, TIMP\u20101, and TIMP\u20102 were evaluated in patients with resected NSCLC, and their associations with disease progression and prognosis were determined.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Between June 1996 and December 1999, 116 patients underwent resection for NSCLC. Expression levels of MMPs and TIMPs were evaluated using Northern blot analysis in these NSCLC tissue samples and in 39 matched samples of normal lung tissue.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>MMP\u20101, MMP\u20109, and TIMP\u20101 expression levels were increased in tumor samples compared with matched, corresponding normal tissues. In contrast, TIMP\u20102 expression was decreased in tumor samples. MMP\u20101 tumor expression was correlated significantly with the evolution of lymph node status and tumor\u2010lymph node\u2010metastasis (TNM) stage. In contrast, MMP\u20109 tumor expression was correlated significantly with increased T stage. TIMP\u20101 overexpression was an independent predictor of worse survival in patients with NSCLC that was not associated with other prognosis factors, such as TNM stage.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>The overexpression of TIMP\u20101 was an independent prognostic marker in patients with NSCLC, and evaluating TIMP\u20101 may be important for identifying patients who are at greater risk of disease recurrence. Cancer 2005. \u00a9 2005 American Cancer Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.20965","type":"journal-article","created":{"date-parts":[[2005,3,7]],"date-time":"2005-03-07T18:20:14Z","timestamp":1110219614000},"page":"1676-1684","source":"Crossref","is-referenced-by-count":68,"title":["Tissue inhibitor of metalloproteinase 1 is an independent predictor of prognosis in patients with nonsmall cell lung carcinoma who undergo resection with curative 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