{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T22:11:11Z","timestamp":1783635071632,"version":"3.55.0"},"reference-count":22,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2005,4,11]],"date-time":"2005-04-11T00:00:00Z","timestamp":1113177600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2005,5,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>The objective of this study was to understand the attitudes and preferences of risk\u2010eligible women regarding use of tamoxifen for breast cancer risk reduction.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>A cross\u2010sectional, mixed\u2010methods interview study was conducted at a university medical center and at community sites. Participants were women who had an estimated 5\u2010year breast cancer risk \u2265 1.7% and no prior breast cancer. Interviews were conducted in English or Spanish. The interview included a 15\u2010minute, standardized educational session on the potential benefits and harms of tamoxifen followed by close\u2010ended and open\u2010ended questions about participants' inclinations to take tamoxifen and factors important to their decision. A demographic questionnaire, a test on knowledge of potential benefits and harms of tamoxifen, and an interview evaluation were included.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Two hundred fifty\u2010five women completed interviews. Their estimated mean 5\u2010year breast cancer risk was 2.8%; and their mean self\u2010perceived 5\u2010year risk was 32.7%. After the educational intervention, 45 women (17.6%) were inclined to take tamoxifen. Very high risk women (&gt; 3.5%) were no more inclined to take it than women with lower risk (1.7\u20133.5%). In a multivariable analysis, lower income, confidence in the effectiveness of tamoxifen, and concern about fractures were associated with being inclined to take it; concern about pulmonary embolism, dyspareunia, cataracts, and low self\u2010perceived breast cancer risk were associated negatively with taking tamoxifen. Participants expressed concerns about adverse effects.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>Less than 20% of women were interested in tamoxifen after education about potential benefits and harms, despite a very high self\u2010perceived breast cancer risk. Candidate chemoprevention agents must have few potential adverse effects to achieve widespread acceptance. Cancer 2005. \u00a9 2005 American Cancer Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.20981","type":"journal-article","created":{"date-parts":[[2005,4,11]],"date-time":"2005-04-11T15:33:44Z","timestamp":1113233624000},"page":"1996-2005","source":"Crossref","is-referenced-by-count":66,"title":["Preferences of Women Evaluating Risks of Tamoxifen (POWER) study of preferences for tamoxifen for breast cancer risk reduction"],"prefix":"10.1002","volume":"103","author":[{"given":"Joy","family":"Melnikow","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debora","family":"Paterniti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahman","family":"Azari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Kuenneth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Birch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam","family":"Kuppermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Nuovo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet","family":"Keyzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart","family":"Henderson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,4,11]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)11423-4"},{"key":"e_1_2_6_3_2","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1093\/jnci\/90.18.1371","article-title":"Tamoxifen for prevention of breast cancer: report of the National Surgical Adjuvant Breast and Bowel Project P\u20101 study","volume":"90","author":"Fisher B","journal-title":"J Natl Cancer Inst."},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)04394-3"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)85012-5"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)09962-2"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)12342-2"},{"key":"e_1_2_6_8_2","first-page":"378","article-title":"Tamoxifen for breast cancer prevention: safety warning","volume":"167","author":"Wooltorton E","year":"2002","journal-title":"CMAJ."},{"key":"e_1_2_6_9_2","first-page":"1681","article-title":"Chemoprevention of breast cancer. 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