{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T15:35:39Z","timestamp":1770824139497,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2005,3,4]],"date-time":"2005-03-04T00:00:00Z","timestamp":1109894400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2005,4,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>The E\u2010cadherin\u2013mediated cell adhesion system is frequently inactivated by multiple mechanisms and is involved in tumor progression in many types of cancer. Recently, the authors reported a novel cell membrane glycoprotein, dysadherin, which has an anti\u2013cell\u2010cell adhesion function and down\u2010regulates E\u2010cadherin.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Expression of both dysadherin and E\u2010cadherin was investigated immunohistochemically in 115 patients with cutaneous malignant melanoma to determine the correlation between the 2 molecules and their associations with both patient survival and the clinicopathologic features of the tumors.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Dysadherin and E\u2010cadherin were expressed at the cell membranes of melanoma cells. Fifty\u2010two percent of the tumors showed dysadherin immunopositivity, and 91% of the tumors showed reduced E\u2010cadherin immunopositivity. There was no significant inverse correlation between dysadherin expression and E\u2010cadherin expression. Increased dysadherin expression was significantly correlated with nodular subtype (<jats:italic>P<\/jats:italic> = 0.042), Clark level (<jats:italic>P<\/jats:italic> &lt; 0.001), tumor thickness (<jats:italic>P<\/jats:italic> &lt; 0.001), ulceration (<jats:italic>P<\/jats:italic> = 0.008), lymph node metastasis (<jats:italic>P<\/jats:italic> &lt; 0.001), high TNM classification (<jats:italic>P<\/jats:italic> &lt; 0.001), and poor patient survival (<jats:italic>P<\/jats:italic> &lt; 0.001). Multivariate analysis of patient survival revealed that increased dysadherin expression was a significant predictor of poor survival (<jats:italic>P<\/jats:italic> &lt; 0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>Thus, increased expression of dysadherin was a significant indicator of poor prognosis in patients with cutaneous malignant melanoma. Cancer 2005. \u00a9 2005 American Cancer Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.20984","type":"journal-article","created":{"date-parts":[[2005,3,4]],"date-time":"2005-03-04T19:16:48Z","timestamp":1109963808000},"page":"1693-1700","source":"Crossref","is-referenced-by-count":33,"title":["Clinicopathologic significance of dysadherin expression in cutaneous malignant 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