{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T11:47:06Z","timestamp":1790855226821,"version":"4.1.0"},"reference-count":14,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2005,3,23]],"date-time":"2005-03-23T00:00:00Z","timestamp":1111536000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2005,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Anaplastic thyroid carcinoma (ATC) is one of the most fulminant human malignancies. However, the molecular carcinogenic mechanisms of ATC are understood poorly. Recently, the authors performed a cyclic DNA (cDNA) microarray analysis with 11 anaplastic thyroid carcinoma cell lines (ACLs) and discovered several novel responsible genes for ACLs and ATC. From the extended list, they focused on hypothetical and anonymous genes and investigated a novel gene, named the overexpressed in anaplastic thyroid carcinoma\u20101 (<jats:italic>OEATC\u20101<\/jats:italic>) gene.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>To investigate the role of the <jats:italic>OEATC\u20101<\/jats:italic> gene in ATC carcinogenesis, first, the expression levels of <jats:italic>OEATC\u20101<\/jats:italic> in ACLs, in various types of carcinoma cell lines, and in normal human tissues were examined with reverse transcriptase\u2010polymerase chain reaction analysis. To explore the effect of <jats:italic>OEATC\u20101<\/jats:italic> in ATC development, a cell\u2010growth assay was performed with KTA2 cells under <jats:italic>OEATC\u20101<\/jats:italic> gene silencing using small\u2010interfering RNA (siRNA).<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p><jats:italic>OEATC\u20101<\/jats:italic> was overexpressed significantly in ACLs and in other types of carcinoma cell lines with various expression levels. Conversely, in normal human tissues, <jats:italic>OEATC\u20101<\/jats:italic> was expressed weakly in placenta, kidney, spleen, thymus, small intestine, and thyroid gland. To evaluate the effects of <jats:italic>OEATC\u20101<\/jats:italic> on tumor cell growth, gene silencing was caused by transfecting the plasmid\u2010generating siRNA effect to KTA2 cells. Consequently, the silencing of <jats:italic>OEATC\u20101<\/jats:italic> significantly suppressed the cell growth compared with controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>The current results indicated that <jats:italic>OEATC\u20101<\/jats:italic> may have some oncogenic or cell growth\u2010promoting function in ACL. <jats:italic>OEATC\u20101<\/jats:italic> is considered a novel responsible gene in ATC. Cancer 2005. \u00a9 2005 American Cancer Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.20988","type":"journal-article","created":{"date-parts":[[2005,3,23]],"date-time":"2005-03-23T19:45:08Z","timestamp":1111607108000},"page":"1785-1790","source":"Crossref","is-referenced-by-count":43,"title":["Overexpressed in anaplastic thyroid carcinoma\u20101 (<i>OEATC\u20101<\/i>) as a novel gene responsible for anaplastic thyroid carcinoma"],"prefix":"10.1002","volume":"103","author":[{"given":"Kazunori","family":"Mizutani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masamitsu","family":"Onda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinichi","family":"Asaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junko","family":"Akaishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shizuyo","family":"Miyamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Yoshida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuji","family":"Nagahama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kouichi","family":"Ito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuru","family":"Emi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,4,18]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002689900610"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004230050205"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1677\/erc.1.00818"},{"key":"e_1_2_6_5_2","first-page":"5007","article-title":"Identification by cDNA microarray of genes involved in ovarian carcinogenesis","volume":"60","author":"Ono K","year":"2000","journal-title":"Cancer Res."},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1068999"},{"key":"e_1_2_6_7_2","first-page":"3444","article-title":"Microsatellite instability in thyroid cancer: hot spots, clinicopathological implications, and prognostic significance","volume":"7","author":"Onda M","year":"2001","journal-title":"Clin Cancer Res."},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10038-004-0146-3"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncb985"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.1992.tb02761.x"},{"key":"e_1_2_6_11_2","first-page":"1811","article-title":"Frequent mutation and nuclear localization of beta\u2010catenin in anaplastic thyroid carcinoma","volume":"59","author":"Garcia\u2010Rostan G","year":"1999","journal-title":"Cancer Res."},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2264(200003)27:3<244::AID-GCC4>3.0.CO;2-7"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.10016"},{"key":"e_1_2_6_14_2","first-page":"3164","article-title":"Genomic alterations in malignant transformation of Barrett's esophagus","volume":"61","author":"Riegman PH","year":"2001","journal-title":"Cancer Res."},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9071(200004)60:4<425::AID-JMV10>3.0.CO;2-A"}],"container-title":["Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcncr.20988","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cncr.20988","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T13:44:49Z","timestamp":1760276689000},"score":1,"resource":{"primary":{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/10.1002\/cncr.20988"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,4,18]]},"references-count":14,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2005,5]]}},"alternative-id":["10.1002\/cncr.20988"],"URL":"https:\/\/doi.org\/10.1002\/cncr.20988","archive":["Portico"],"relation":{},"ISSN":["0008-543X","1097-0142"],"issn-type":[{"value":"0008-543X","type":"print"},{"value":"1097-0142","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,4,18]]}}}