{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T02:48:39Z","timestamp":1773283719530,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2005,4,8]],"date-time":"2005-04-08T00:00:00Z","timestamp":1112918400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2005,5,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Several studies have recently suggested an association between body mass index (BMI) and disease progression after radical prostatectomy. In the current study, the authors examined this association and that between the reciprocal of BMI (INVBMI, 1\/BMI) and progression\u2010free probability in men treated with radical retropubic prostatectomy (RRP) for clinically localized prostate carcinoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>The authors retrospectively studied 2210 patients who underwent RRP at Memorial Sloan\u2010Kettering Cancer Center between September 1986 and May 2003. Clinicopathologic variables analyzed included BMI (kg\/m<jats:sup>2<\/jats:sup>), preoperative serum prostate\u2010specific antigen level (ng\/mL), clinical T classification, year of surgery, race, biopsy\u2010derived primary and secondary Gleason grades, and INVBMI, known to better correlate with percent body fat than BMI. Cox regression analysis was used to examine the possible association between BMI or its reciprocal with disease progression after controlling for the effects of common prognostic factors. The areas under the receiver operating curve (AUC) for models with and without INVBMI were calculated<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Of the 2210 patients analyzed, 251 experienced disease progression in a median follow\u2010up time of 25.9 months (range, 0\u2013143 months). After adjusting for all clinical variables, both BMI (<jats:italic>P<\/jats:italic> = 0.071; hazards ratio [HR] = 1.027) and INVBMI (<jats:italic>P<\/jats:italic> = 0.041; HR &lt; 0.001) were associated with disease progression. However, the areas under AUC for models with and without INVBMI were similar (range, 0.794\u20130.798).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>Although conflicting evidence has been reported regarding the link between obesity and an increased risk of developing prostate carcinoma, as well as an increased risk of developing aggressive disease and prostate carcinoma\u2010related mortality, the authors found weak associations with disease progression for both BMI and INVBMI. These variables were of negligible prognostic value in men who received surgery. Studies with longer follow\u2010up, that examine alternative end points, and that follow treatment(s) besides surgery are needed. Cancer 2005. \u00a9 2005 American Cancer Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.20991","type":"journal-article","created":{"date-parts":[[2005,4,8]],"date-time":"2005-04-08T12:50:54Z","timestamp":1112964654000},"page":"2030-2034","source":"Crossref","is-referenced-by-count":53,"title":["Body mass index is weakly associated with, and not a helpful predictor of, disease progression in men with clinically localized prostate carcinoma treated with radical prostatectomy"],"prefix":"10.1002","volume":"103","author":[{"given":"Kozhaya N.","family":"Mallah","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher J.","family":"DiBlasio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Audrey C.","family":"Rhee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter T.","family":"Scardino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael W.","family":"Kattan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,4,8]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.288.14.1723"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.3998\/mpub.12198"},{"key":"e_1_2_5_4_2","unstructured":"FlegalKM.Anthropometric evaluation of obesity in epidemiologic research on risk factors: blood pressure and obesity in the health examination survey. PhD dissertation (UMI: 8228449) Cornell University 1982."},{"key":"e_1_2_5_5_2","first-page":"93S","article-title":"Is an inverted weight\u2010height index a better index of body fatness","volume":"5","author":"Flegal KM","year":"1997","journal-title":"Obes Res."},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/77.1.71"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa021423"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.11266"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.3322\/canjclin.54.1.8"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.pcan.4500514"},{"key":"e_1_2_5_11_2","first-page":"1335","article-title":"Body size and prostate cancer: a population\u2010based case\u2010control study in China","volume":"9","author":"Hsing AW","year":"2000","journal-title":"Cancer Epidemiol Biomarkers Prev."},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a010241"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-410X.2003.04133.x"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(01)01373-5"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.03.132"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0045(200101)46:1<62::AID-PROS1009>3.0.CO;2-V"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.04.181"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(20000301)88:5<1122::AID-CNCR24>3.0.CO;2-Q"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.10967"},{"key":"e_1_2_5_20_2","unstructured":"Physical status: the use and interpretation of anthropometry. 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