{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T11:06:18Z","timestamp":1788606378037,"version":"build-2803163510"},"reference-count":33,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2005,3,16]],"date-time":"2005-03-16T00:00:00Z","timestamp":1110931200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2005,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>An increasing incidence of oral carcinoma among young adults has been reported in the U.S. and Europe. Although the association between human papillomavirus infection and tonsillar carcinoma is now well established, to the authors' knowledge little is known about incidence trends in tonsillar carcinoma among younger adults. The objective of the current study was to explore the trends in both oral cavity and pharyngeal squamous cell carcinoma (SCC) in younger U.S. populations, in particular tongue and tonsillar SCC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>Using the 1973\u20132001 Surveillance, Epidemiology and End Results (SEER) database, we computed age, race, and site\u2010specific trends of oral and pharyngeal (excluding nasopharynx) carcinoma incidence rates. The percent change (PC) and annual percent change (APC) were computed to explore trends in incidence rates over time.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      There were 2262 SCC of the oral cavity and 1251 SCC of the pharynx reported to the SEER program from 1973 to 2001 in adults aged 20\u201344 years. There was a statistically significant increase in the incidence of oral tongue SCC (APC = +2.1;\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.001), base of tongue SCC (APC = +1.7;\n                      <jats:italic>P<\/jats:italic>\n                      = 0.04), and palatine tonsil SCC (APC = +3.9;\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.001) among younger white individuals, whereas the incidence of SCC in all other oral and pharyngeal sites decreased or remained constant.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>The increase in tonsil SCC incidence from 1973 to 2001 paralleled the increase in tongue SCC, whereas SCC in all other oral and pharyngeal sites remained constant or decreased. This may suggest similar etiologic factors for SCC affecting the palatine tonsils and tongue in younger populations. Cancer 2005. \u00a9 2005 American Cancer Society.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncr.20998","type":"journal-article","created":{"date-parts":[[2005,3,16]],"date-time":"2005-03-16T18:16:26Z","timestamp":1110996986000},"page":"1843-1849","source":"Crossref","is-referenced-by-count":620,"title":["Tongue and tonsil carcinoma"],"prefix":"10.1002","volume":"103","author":[{"given":"Caroline H.","family":"Shiboski","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian L.","family":"Schmidt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard C. K.","family":"Jordan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,4,18]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20288"},{"key":"e_1_2_5_3_2","doi-asserted-by":"crossref","first-page":"1857","DOI":"10.1001\/jama.1984.03350140017016","article-title":"Increase of tongue cancer in young men","volume":"252","author":"Shemen L","year":"1984","journal-title":"JAMA."},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198609043151013"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(87)91393-6"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0528.2000.280402.x"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-5998(00)70142-2"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.128.3.268"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.10577"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.43.11.918"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0215(20000520)89:3<300::AID-IJC14>3.0.CO;2-G"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(20011201)92:11<2875::AID-CNCR10130>3.0.CO;2-7"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001622-200105000-00009"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/92.9.709"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910510602"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/00008469-200012000-00010"},{"key":"e_1_2_5_17_2","unstructured":"Surveillance Epidemiology and End Results (SEER) program (SEER*Stat database. Incidence \u2010 SEER 9 Regs Public\u2010Use November 2003 submission (1973\u20102001) April 2004 release based on the November2003submission. Available from URL:www.seer.cancer.gov[accessed November 2004]."},{"key":"e_1_2_5_18_2","volume-title":"SEER cancer statistics review, 1973\u20101994. NIH Pub. No. 97\u20102789","author":"Ries LAG","year":"1997"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19951201)76:11<2343::AID-CNCR2820761124>3.0.CO;2-#"},{"key":"e_1_2_5_20_2","first-page":"2821","article-title":"Human papillomavirus and DNA ploidy in tonsillar cancer \u2010 correlation to prognosis","volume":"23","author":"Mellin H","year":"2003","journal-title":"Anticancer Res."},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.11261"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1067\/mhn.2001.116979"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19980504)76:3<341::AID-IJC10>3.0.CO;2-E"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1386-6532(00)00126-8"},{"key":"e_1_2_5_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3800155"},{"key":"e_1_2_5_26_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200311000-00010"},{"key":"e_1_2_5_27_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1993.tb01038.x"},{"key":"e_1_2_5_28_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djg107"},{"key":"e_1_2_5_29_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.20490"},{"key":"e_1_2_5_30_2","doi-asserted-by":"publisher","DOI":"10.1086\/381504"},{"key":"e_1_2_5_31_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/90.21.1626"},{"key":"e_1_2_5_32_2","first-page":"1071","article-title":"Marijuana use and increased risk of squamous cell carcinoma of the head and neck","volume":"8","author":"Zhang Z","year":"1999","journal-title":"Cancer Epidemiol Biomark Prev."},{"key":"e_1_2_5_33_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-03-3425"},{"key":"e_1_2_5_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1368-8375(00)00135-4"}],"container-title":["Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcncr.20998","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cncr.20998","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T13:44:33Z","timestamp":1760276673000},"score":1,"resource":{"primary":{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/10.1002\/cncr.20998"}},"subtitle":["Increasing trends in the U.S. population ages 20\u201344 years"],"short-title":[],"issued":{"date-parts":[[2005,4,18]]},"references-count":33,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2005,5]]}},"alternative-id":["10.1002\/cncr.20998"],"URL":"https:\/\/doi.org\/10.1002\/cncr.20998","archive":["Portico"],"relation":{},"ISSN":["0008-543X","1097-0142"],"issn-type":[{"value":"0008-543X","type":"print"},{"value":"1097-0142","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,4,18]]}}}