{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T08:43:47Z","timestamp":1762505027103,"version":"build-2065373602"},"reference-count":41,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2005,4,15]],"date-time":"2005-04-15T00:00:00Z","timestamp":1113523200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2005,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Deletions of 19q have been associated with gliomas, especially oligodendrogliomas. In addition, cases with oligodendrogliomas with the 19q deletion have been observed to have a better survival compared with cases without the 19q deletion. The authors have previously described a 150\u2010kilobase minimal deletion region in gliomas that maps to 19q13.33 and contains 3 novel candidate genes (<jats:italic>GLTSCR1<\/jats:italic>, <jats:italic>EHD2<\/jats:italic>, and <jats:italic>GLTSCR2<\/jats:italic>).<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>The authors performed an association study using 141 cases with gliomas (61 cases with astrocytomas, 40 cases with oligodendrogliomas, 40 cases with mixed oligoastrocytomas) and 108 general controls. They evaluated 7 single nucleotide polymorphisms (SNPs) in 6 genes within and nearby the minimal 19q deletion region (<jats:italic>ERCC2<\/jats:italic>, <jats:italic>RAI<\/jats:italic>, <jats:italic>ASE\u20101<\/jats:italic>, <jats:italic>ERCC1<\/jats:italic>, <jats:italic>GLTSCR1<\/jats:italic>, and <jats:italic>LIG1<\/jats:italic>).<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>The prevalence of a germline <jats:italic>GLTSCR1<\/jats:italic>\u2010exon\u20101 T allele (SNP rs1035938) was 40% in cases with oligodendrogliomas compared with 27% in controls (<jats:italic>P<\/jats:italic> = 0.029), and the prevalence of an ERCC2\u2010exon\u201022 T allele (SNP rs1052555) was 35% in cases with oligodendrogliomas compared with 18% in controls (<jats:italic>P<\/jats:italic> = 0.043). One high\u2010risk and 1 low\u2010risk haplotype were associated with oligodendroglioma development (<jats:italic>P<\/jats:italic> = 0.003 and 0.026, respectively). Cases with oligodendrogliomas with the 19q deletion had a significantly higher frequency of the <jats:italic>GLTSCR1<\/jats:italic>\u2010exon\u20101 T allele compared with cases without the 19q deletion (<jats:italic>P<\/jats:italic> = 0.01). It was noteworthy that cases with gliomas who were homozygous for the <jats:italic>GLTSCR1<\/jats:italic>\u2010exon\u20101 T allele had a significantly better survival: 77% and 68% survival at 2 and 5 years compared with 56% and 34% for other genotypes (<jats:italic>P<\/jats:italic> = 0.02, log\u2010rank test). Multivariable analysis identified grade, age, and the <jats:italic>GLTSCR1<\/jats:italic>\u2010exon\u20101 and ERCC2\u2010exon\u201022 genotypes as independent predictors for survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>These results suggested that alterations in <jats:italic>GLTSCR1<\/jats:italic> (or a closely linked gene) were associated with the development and progression of oligodendroglioma. Cancer 2005. \u00a9 2005 American Cancer Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.21028","type":"journal-article","created":{"date-parts":[[2005,4,15]],"date-time":"2005-04-15T16:17:31Z","timestamp":1113581851000},"page":"2363-2372","source":"Crossref","is-referenced-by-count":57,"title":["Polymorphisms in <i>GLTSCR1<\/i> and <i>ERCC2<\/i> are associated with the development of oligodendrogliomas"],"prefix":"10.1002","volume":"103","author":[{"given":"Ping","family":"Yang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas M.","family":"Kollmeyer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristin","family":"Buckner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William","family":"Bamlet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karla 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