{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T23:15:44Z","timestamp":1771629344049,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2005,4,8]],"date-time":"2005-04-08T00:00:00Z","timestamp":1112918400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2005,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Portal vein thrombosis (PVT) is a common complication in patients with advanced\u2010stage hepatocellular carcinoma (HCC). The authors evaluated the impact of radiotherapy (RT) for PVT of HCC and analyzed the dose\u2010response relation between RT and PVT.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Between March 1995 and December 2003, 59 patients diagnosed as HCC with PVT were included. The inclusion criteria were unresectable tumor with thrombosis in the main or first branch of the portal vein, liver function of Child\u2013Pugh Class A or B, and an Eastern Cooperative Oncology Group performance status score of 0\u20132. The median age of the patients was 57 years (range, 36\u201378 years). A daily dose ranging from 2 to 3 gray (Gy) was administered using 6 or 10\u2010megavolt (MV) X\u2010rays, at 5 fractions a week, to deliver a total dose range of 30\u201354 Gy, which was a biologic effective dose of 39\u201370.2 Gy<jats:sub>10<\/jats:sub> with an \u03b1\/\u03b2 ratio of 10.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Follow\u2010up computed tomography scans showed a complete response (CR) in 4 of 59 patients (6.8%), a partial response (PR) in 23 patients (39.0%), no response (NR) in 28 patients (47.5%), and progressive disease (PD) in 4 patients (6.8%). The mean RT doses in the responders (CR and PR) and nonresponders (NR and PD) were 59.6 \u00b1 5.6 Gy<jats:sub>10<\/jats:sub> and 54.9 \u00b1 8.5 Gy<jats:sub>10<\/jats:sub>, respectively (<jats:italic>P<\/jats:italic> = 0.036). The response rates in patients receiving &lt; 58 Gy<jats:sub>10<\/jats:sub> and \u2265 58 Gy<jats:sub>10<\/jats:sub> were 20% and 54.6%, respectively (<jats:italic>P<\/jats:italic> = 0.034). The median survival duration and the 1\u2010year and 2\u2010year survival rates in the responders were 10.7 months, 40.7%, and 20.7%, respectively, and were 5.3 months, 25.0%, and 4.7%, respectively, in the nonresponders (<jats:italic>P<\/jats:italic> = 0.050).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>RT induced a 45.8% objective response rate for PVT in patients with HCC. A dose\u2010response relation was found to exist between the RT dose and PVT response. These results suggested that RT may be a treatment option for PVT in patients with HCC and that an RT dose \u2265 58 Gy<jats:sub>10<\/jats:sub> should be recommended. Cancer 2005. \u00a9 2005 American Cancer Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.21043","type":"journal-article","created":{"date-parts":[[2005,4,8]],"date-time":"2005-04-08T12:48:13Z","timestamp":1112964493000},"page":"2419-2426","source":"Crossref","is-referenced-by-count":149,"title":["Three\u2010dimensional conformal radiotherapy for portal vein thrombosis of hepatocellular carcinoma"],"prefix":"10.1002","volume":"103","author":[{"given":"Dae Yong","family":"Kim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Won","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Do Hoon","family":"Lim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joon Hyoek","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Byung Chul","family":"Yoo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung Woon","family":"Paik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kwang Cheol","family":"Kho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tae Hyun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong Chan","family":"Ahn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung Jae","family":"Huh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,4,8]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(85)90327-0"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-67-2-337"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-9260(05)80923-7"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.197.1.7568806"},{"key":"e_1_2_5_6_2","first-page":"481","article-title":"Surgical treatment of 109 patients with symptomatic and asymptomatic hepatocellular carcinoma","volume":"99","author":"Lee CS","year":"1986","journal-title":"Surgery."},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.154.5.2157329"},{"key":"e_1_2_5_8_2","first-page":"165","article-title":"Risk factors of early recurrence after curative hepatic resection for hepatocellular carcinoma","volume":"31","author":"Choi JH","year":"1999","journal-title":"J Korean Cancer Assoc."},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19970601)79:11<2087::AID-CNCR5>3.0.CO;2-M"},{"key":"e_1_2_5_10_2","first-page":"200","article-title":"Radiation hepatitis","volume":"93","author":"Ingold JA","year":"1965","journal-title":"Am J Roentgenol Radium Ther Nucl Med."},{"key":"e_1_2_5_11_2","first-page":"21","article-title":"Human radiation hepatitis. A morphologic study with emphasis on the late changes","volume":"96","author":"Lewin K","year":"1973","journal-title":"Arch Pathol."},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(92)90651-W"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000421-200204000-00019"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(00)00462-4"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(00)00519-8"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1746.1999.01994.x"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1746.2001.02496.x"},{"key":"e_1_2_5_18_2","first-page":"918","article-title":"Dose\u2010response relationship of radiotherapy for locally advanced hepatocellular carcinoma","volume":"32","author":"Kim DY","year":"2000","journal-title":"J Korean Cancer Assoc."},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(02)02864-X"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1259\/bjr.73.874.11271902"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1259\/0007-1285-62-740-679"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(91)90069-G"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/jso.2930560113"},{"key":"e_1_2_5_24_2","first-page":"105","article-title":"Hepatocellular carcinoma with portal tumor thrombus: analysis of factors determining prognosis","volume":"23","author":"Fujii T","year":"1993","journal-title":"Jpn J Clin Oncol."},{"key":"e_1_2_5_25_2","first-page":"637","article-title":"Implications of surgical treatment for advanced hepatocellular carcinoma with tumor thrombi in the portal vein","volume":"43","author":"Tanaka A","year":"1996","journal-title":"Hepatogastroenterology."},{"key":"e_1_2_5_26_2","first-page":"821","article-title":"Hepatic resection for advanced hepatocellular carcinoma with removal of portal vein tumor thrombi","volume":"108","author":"Kumada K","year":"1990","journal-title":"Surgery."},{"key":"e_1_2_5_27_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.148.2.6306721"},{"key":"e_1_2_5_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.10246"},{"key":"e_1_2_5_29_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.10694"},{"key":"e_1_2_5_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(196007\/08)13:4<714::AID-CNCR2820130411>3.0.CO;2-3"},{"key":"e_1_2_5_31_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1985.3.12.1573"},{"key":"e_1_2_5_32_2","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/hyh089"},{"key":"e_1_2_5_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(03)00434-6"},{"key":"e_1_2_5_34_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1993.11.7.1286"},{"key":"e_1_2_5_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(96)00528-7"}],"container-title":["Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcncr.21043","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cncr.21043","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T17:57:54Z","timestamp":1760291874000},"score":1,"resource":{"primary":{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/10.1002\/cncr.21043"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,4,8]]},"references-count":34,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2005,6]]}},"alternative-id":["10.1002\/cncr.21043"],"URL":"https:\/\/doi.org\/10.1002\/cncr.21043","archive":["Portico"],"relation":{},"ISSN":["0008-543X","1097-0142"],"issn-type":[{"value":"0008-543X","type":"print"},{"value":"1097-0142","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,4,8]]}}}