{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T23:13:51Z","timestamp":1792192431651,"version":"4.4.0"},"reference-count":6,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,5,11]],"date-time":"2005-05-11T00:00:00Z","timestamp":1115769600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2005,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Despite the absence of any systematic evidence for diagnostic utility, red cell mass (RCM) measurement has been endorsed as a major diagnostic criterion for polycythemia vera (PV) based on a set of eligibility criteria for a clinical trial formulated by an International PV Study Group in 1967.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>A retrospective analysis was performed on a consecutive series of 105 patients who underwent blood volume measurements for evaluation of polycythemia. In a previous study, the authors had systematically compared RCM measurement by <jats:sup>51<\/jats:sup>Cr\u2010labeled erythrocytes and <jats:sup>125<\/jats:sup>I\u2010labeled human serum albumin and demonstrated equivalence between the two methods. In the current study, they used the latter method and applied the International Committee for Standardization in Haematology recommendations for result interpretation in order to evaluate test performance and practical utility.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>RCM exceeded the 98\u201399% limits of the reference range in 76%, 20%, 22%, and 57% of patients with PV (<jats:italic>n<\/jats:italic> = 25), secondary polycythemia (<jats:italic>n<\/jats:italic> = 35), spurious or apparent polycythemia (<jats:italic>n<\/jats:italic> = 38), and essential thrombocythemia (<jats:italic>n<\/jats:italic> = 7), respectively. Decreased plasma volume was rarely seen in any of the disease categories. In all instances of PV, the diagnosis was readily apparent, based on alternative clinical and laboratory tests, and did not require the additional information from blood volume measurement. Furthermore, alternative methods of PV diagnosis, based on disease\u2010specific biological markers as well as bone marrow histology, are now available.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>The continued use of RCM and plasma volume measurements for the diagnosis of PV is no longer warranted. Cancer 2005. \u00a92005 American Cancer Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.21105","type":"journal-article","created":{"date-parts":[[2005,5,19]],"date-time":"2005-05-19T16:18:48Z","timestamp":1116519528000},"page":"213-215","source":"Crossref","is-referenced-by-count":36,"title":["Red cell mass and plasma volume measurements in polycythemia:"],"prefix":"10.1002","volume":"104","author":[{"given":"Shireen","family":"Sirhan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virgil F.","family":"Fairbanks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayalew","family":"Tefferi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,6,17]]},"reference":[{"key":"e_1_2_5_2_2","first-page":"483","article-title":"The treatment of polycythemia. A panel discussion","volume":"32","author":"Wasserman LR","year":"1968","journal-title":"Blood."},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.4065\/78.2.174"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1006\/bcmd.1996.0024"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1995.tb08411.x"},{"key":"e_1_2_5_6_2","article-title":"Management of patients with polycythaemia vera: results of a survey among Swedish haematologists","author":"Andreasson B","journal-title":"Eur J Haematol."},{"key":"e_1_2_5_7_2","first-page":"422","article-title":"Effect of obesity on red cell mass results","volume":"40","author":"Leslie WD","year":"1999","journal-title":"J Nucl Med."}],"container-title":["Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcncr.21105","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cncr.21105","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T18:56:01Z","timestamp":1760295361000},"score":1,"resource":{"primary":{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/10.1002\/cncr.21105"}},"subtitle":["Evaluation of performance and practical utility"],"short-title":[],"issued":{"date-parts":[[2005,6,17]]},"references-count":6,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2005,7]]}},"alternative-id":["10.1002\/cncr.21105"],"URL":"https:\/\/doi.org\/10.1002\/cncr.21105","archive":["Portico"],"relation":{},"ISSN":["0008-543X","1097-0142"],"issn-type":[{"value":"0008-543X","type":"print"},{"value":"1097-0142","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,6,17]]}}}