{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:43:59Z","timestamp":1790297039255,"version":"4.1.0"},"reference-count":38,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,6,3]],"date-time":"2005-06-03T00:00:00Z","timestamp":1117756800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2005,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>The goals of the current study were to elucidate the long\u2010term outcome of <jats:italic>Helicobacter pylori<\/jats:italic> eradication therapy for gastric mucosa\u2010associated lymphoid tissue (MALT) lymphoma and to clarify the therapeutic efficacy of stomach\u2010conserving treatments for patients not responding to eradication therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Ninety\u2010six patients with gastric MALT lymphoma, including 17 patients with areas of diffuse large B\u2010cell lymphoma, were treated by <jats:italic>H. pylori<\/jats:italic> eradication. Patients not responding to eradication therapy underwent either a gastrectomy, multiagent chemotherapy, oral monochemotherapy (OMC), or radiotherapy (RT). Predictive factors for the response to eradication therapy, overall survival (OS), and event\u2010free survival (EFS) were determined by the Kaplan\u2013Meier analysis with the log\u2010rank test. The efficacy of second\u2010line treatment was compared between OMC and RT.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>After eradication therapy, 62 (65%) patients achieved complete disease remission (CR). Transient histologic disease recurrence was confirmed in 4 (6.5%) of 62 patients with CR during the follow\u2010up (median, 37.5 months). The OS and EFS probabilities after 5 years were 0.96 and 0.80, respectively. Second\u2010line treatment was performed in 31 patients; gastrectomy in 4 patients, multiagent chemotherapy in 5 patients, OMC in 12 patients, and RT in 10 patients. There were no differences in the CR rate, OS, EFS, or toxicity between the OMC and RT groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p><jats:italic>H. pylori<\/jats:italic> eradication therapy was an effective first\u2010line treatment for patients with gastric MALT lymphoma, which led to a favorable long\u2010term outcome. OMC and RT had an equivalent efficacy as a second\u2010line treatment in nonresponding patients to eradication therapy. Cancer 2005. \u00a9 2005 American Cancer Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.21152","type":"journal-article","created":{"date-parts":[[2005,6,3]],"date-time":"2005-06-03T18:16:35Z","timestamp":1117822595000},"page":"532-540","source":"Crossref","is-referenced-by-count":69,"title":["Long\u2010term clinical outcome of <i>Helicobacter pylori<\/i> eradication for gastric mucosa\u2010associated lymphoid tissue lymphoma with a reference to second\u2010line treatment"],"prefix":"10.1002","volume":"104","author":[{"given":"Shotaro","family":"Nakamura","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takayuki","family":"Matsumoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Suekane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeo","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Matsumoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motohiro","family":"Esaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuo","family":"Iida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,6,3]]},"reference":[{"key":"e_1_2_5_2_2","volume-title":"Extranodal lymphomas","author":"Isaacson PG","year":"1994"},{"key":"e_1_2_5_3_2","volume-title":"World Health Organization classification of tumours. 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