{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T15:35:51Z","timestamp":1770824151497,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,6,10]],"date-time":"2005-06-10T00:00:00Z","timestamp":1118361600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2005,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Some authors have suggested that the biology of meningiomas differs according to a patient's age. Proliferation, vascularity, and hormonal status in meningiomas can be used to describe changes during aging. In the current study, proliferation activity with the Ki\u201067\/MIB\u20101 antibody was evaluated by immunohistochemistry in meningioma tissue specimens from young and elderly patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Over the past 25 years, tissue samples from 1766 patients with meningiomas were evaluated. Of these, 588 tumor specimens from 554 patients who underwent surgery between 1990 and 2000 were evaluated immunohistochemically. The proliferation index (LI) and progesterone receptor (PR) in meningiomas were quantitatively estimated in elderly (age \u2265 70 years) and young patients (age &lt; 70 years). Patients' charts including surgical records, discharge letters, pathology reports, and imaging studies were reviewed. Correlations with histologic subtype, disease recurrence\u2010free survival, resection grade, location, size, vascularity, and tumor calcification were calculated as well. Only patients with a well documented follow\u2010up were included in the statistical evaluation (<jats:italic>n<\/jats:italic> = 385).<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Compared with the young group of 344 patients with meningioma (age &lt; 70 years; mean age, 51.9 years; range, 18\u201369 years), the elderly population (age \u2265 70 years; <jats:italic>n<\/jats:italic> = 41; mean age, 74.9 years; range, 70\u201388 years) showed a male\u2010to\u2010female ratio of 3.2: 1. Both groups had an identical median Ki\u201067 LI of 3.0% and a PR status of 56.1% versus 58.4 %. No statistically significant differences in disease recurrence\u2010free survival could be found in the two groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>Proliferation rates and PR status in benign intracranial meningiomas did not appear to be age dependent. Cancer 2005. \u00a9 2005 American Cancer Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.21192","type":"journal-article","created":{"date-parts":[[2005,6,10]],"date-time":"2005-06-10T15:16:41Z","timestamp":1118416601000},"page":"598-601","source":"Crossref","is-referenced-by-count":30,"title":["Proliferation and progesterone receptor status in benign meningiomas are not age dependent"],"prefix":"10.1002","volume":"104","author":[{"given":"Florian","family":"Roser","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makoto","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rainer","family":"Ritz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mattia","family":"Bellinzona","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaus","family":"Dietz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Madjid","family":"Samii","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcos S.","family":"Tatagiba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6,10]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01401421"},{"key":"e_1_2_5_3_2","first-page":"153","volume-title":"Meningiomas","author":"Rengachary S","year":"1991"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1227\/00006123-198904000-00011"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01405421"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1227\/00006123-199502000-00005"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0090-3019(94)90241-0"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19990515)85:10<2249::AID-CNCR21>3.0.CO;2-5"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.68.1.25"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3639.1993.tb00752.x"},{"key":"e_1_2_5_11_2","first-page":"138","article-title":"Recommendation for uniform definition of an immunoreactive score (IRS) for immunohistochemical estrogen receptor detection (ER\u2010ICA) in breast cancer tissue","volume":"8","author":"Remmele W","year":"1987","journal-title":"Pathologe."},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.20.1.22"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s007010050209"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s101430050027"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2004.018333"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1227\/01.NEU.0000068730.76856.58"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1995.83.2.0222"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s007010050463"},{"key":"e_1_2_5_19_2","first-page":"54","article-title":"Les m\u00e9ningiomes r\u00e9cidivantes [Recurrent menginomas]","volume":"32","author":"Philippon J","year":"1986","journal-title":"Neurochirurgie."},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01560565"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.3109\/02688699209002915"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01476411"}],"container-title":["Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcncr.21192","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cncr.21192","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T17:50:45Z","timestamp":1760291445000},"score":1,"resource":{"primary":{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/10.1002\/cncr.21192"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,6,10]]},"references-count":21,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2005,8]]}},"alternative-id":["10.1002\/cncr.21192"],"URL":"https:\/\/doi.org\/10.1002\/cncr.21192","archive":["Portico"],"relation":{},"ISSN":["0008-543X","1097-0142"],"issn-type":[{"value":"0008-543X","type":"print"},{"value":"1097-0142","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,6,10]]}}}