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The incidence, histology, and management of patients with sarcomas were reviewed in the current study.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>The authors reviewed the records of 16,705 patients with breast carcinoma. Of these, 13,472 (81%) were treated with megavoltage radiotherapy and 3233 were treated without at the Institute Curie (Paris, France) between 1981 and 1997. Median doses of 50\u201355 grays (Gy) in 25\u201327 fractions were delivered to the whole breast over a period of 5\u20135.5 weeks (2 Gy\/day, 5 weekly fractions) followed, when indicated, by a 16\u201326\u2010Gy boost to the tumor or tumor bed. Treatment of radiation\u2010induced sarcomas (RIS) consisted mostly of radical surgery and chemotherapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Overall, 35 patients developed sarcomas. Of these, 27 fulfilled the Cahan criteria. The median follow\u2010up was 9.3 years (range, 1\u201322.4 years). The latency period ranged from 3 years to 20.3 years. Thirteen sarcomas were located in the breast, 5\u2013 in the chest wall, 3 in the sternum, 2 in the supraclavicle, 1 in the scapula, and 3 in the axilla. Histologic evaluation identified 13 angiosarcomas, 3 osteosarcomas, 5 undifferentiated sarcomas, 1 malignant fibrous histiocytoma, 2 leiomyosarcomas, 1 fibrosarcoma, 1 rhabdomyosarcoma, and 1 myosarcoma. The cumulative RIS incidence was 0.07% (\u00b1 0.02) at 5 years, 0.27% (\u00b1 0.05) at 10 years, and 0.48% (\u00b1 0.11) at 15 years. Standardized incidence ratios were 10.2 (95% confidence interval, 9.03\u201311.59) for irradiated patients and 1.3 (0.3\u20133.6) for nonirradiated patients. Of the 27 patients, 15 died of sarcoma within 1 month to 14.5 years (mean, 34.2 \u00b1 0.7 months). The 5\u2010year actuarial survival rate after diagnosis of RIS was 36% (\u00b1 0.11).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>The current study confirmed the rarity of RIS. However, it showed that the risk increased with time. Therefore, careful, long\u2010term follow\u2010up of patients treated with radiotherapy is needed for early detection and efficacious treatment of these malignancies. Cancer 2005. \u00a9 2005 American Cancer Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.21223","type":"journal-article","created":{"date-parts":[[2005,6,24]],"date-time":"2005-06-24T21:46:39Z","timestamp":1119649599000},"page":"856-863","source":"Crossref","is-referenced-by-count":221,"title":["Radiation\u2010induced sarcomas after radiotherapy for breast carcinoma"],"prefix":"10.1002","volume":"104","author":[{"given":"Youlia M.","family":"Kirova","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques 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