{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T05:06:51Z","timestamp":1791176811387,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2005,9,21]],"date-time":"2005-09-21T00:00:00Z","timestamp":1127260800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2005,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Although caspase recruitment domain (CARD) membrane\u2010associated guanylate kinase (MAGUK) protein 1 (CARMA1) and CARD9 play important roles in lymphocyte activation, the significance of CARMA1 and CARD9 in the pathogenesis of gastric mucosa\u2010associated lymphoid tissue (MALT) lymphoma remains to be elucidated.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>By using reverse transcription\u2010polymerase chain reaction analysis, the expression levels of mRNA of CARMA1, CARD9, Bcl10, and the apoptosis inhibitor 2 (API2)\u2010MALT1 chimeric transcript were determined in tissue specimens from 65 patients with primary gastric B\u2010cell lymphoma (43 patients with low\u2010grade MALT lymphoma, 16 patients with MALT lymphoma plus diffuse large B\u2010cell lymphoma [DLBL], and 6 patients with DLBL without MALT lymphoma) and in tissue specimens from 18 patients with chronic gastritis. The expression levels of CARMA1 and BCL10 were examined immunohistochemically in 30 patients with lymphoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>CARMA1 mRNA was detected in 55% of lymphoma patients but in only 17% of chronic gastritis patients. The positive rates for CARD9, Bcl10, and API2\u2010MALT1 chimeric transcript in the lymphoma patients were 48%, 98%, and 8%, respectively, whereas the 3 molecules were not detected in any specimens from patients with chronic gastritis. The expression of CARMA1 and CARD9 was frequent in the <jats:italic>Helicobacter pylori<\/jats:italic>\u2010negative patients (100% and 86%, respectively), in the API2\u2010MALT1 chimeric transcript\u2010positive patients (100% and 100%, respectively), and in the specimens from patients who did not respond to <jats:italic>H. pylori<\/jats:italic> eradication (76% and 71%, respectively). In addition, CARMA1 expression was positive more frequently in patients of DLBL without MALT lymphoma (100%) than in patients of MALT lymphoma (51%). CARMA1 protein expression was correlated significantly with the expression of CARMA1 mRNA and also with the expression of nuclear BCL10.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>The overexpression of CARMA1 and CARD9 presumably is associated with the development or progression of gastric B\u2010cell lymphoma, especially among patients who have disease in which the pathogenesis is not related to <jats:italic>H. pylori<\/jats:italic>. Cancer 2005. \u00a9 2005 American Cancer Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.21421","type":"journal-article","created":{"date-parts":[[2005,9,21]],"date-time":"2005-09-21T12:46:49Z","timestamp":1127306809000},"page":"1885-1893","source":"Crossref","is-referenced-by-count":41,"title":["Overexpression of caspase recruitment domain (CARD) membrane\u2010associated guanylate kinase 1 (CARMA1) and CARD9 in primary gastric B\u2010cell lymphoma"],"prefix":"10.1002","volume":"104","author":[{"given":"Shigeo","family":"Nakamura","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shotaro","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takayuki","family":"Matsumoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinichiro","family":"Yada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minako","family":"Hirahashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Suekane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenichi","family":"Goda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuo","family":"Iida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,9,21]]},"reference":[{"key":"e_1_2_5_2_2","volume-title":"Extranodal lymphomas","author":"Isaacson PG","year":"1994"},{"key":"e_1_2_5_3_2","volume-title":"World Health Organization classification of tumours. 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