{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T20:11:49Z","timestamp":1760299909302,"version":"build-2065373602"},"reference-count":30,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2005,10,4]],"date-time":"2005-10-04T00:00:00Z","timestamp":1128384000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2005,11,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Despite radical surgical resection, thymomas often recur. The objective of the current retrospective study was to investigate the prognostic relevance of the expression of cell\u2010cycle proteins in these neoplasms to formulate a possible therapeutic surveillance strategy for the prevention of recurrence.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>The authors retrospectively reviewed the main clinicopathologic factors, including the World Health Organization (WHO) classification, of patients with thymoma who had undergone radical surgical resection. Specimens were studied using immunohistochemistry and the expression of cell\u2010cycle proteins (i.e., p21, p27, and p53) was assessed. Univariate and multivariate analysis of predicting survival prognostic factors were performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>The authors analyzed 88 patients with thymoma who underwent radical surgical resection at the study institution. According to the Masaoka staging system, 41 patients had Stage I disease, 31 patients had Stage II disease, and 16 patients had Stage III disease. There were 24 tumor recurrences (27.3%), 4 of which were local, 16 of which were distant intrathoracic, and 4 of which were extrathoracic. The second radical resection provided a disease\u2010free survival rate that was similar to the first. Only Masaoka stage (<jats:italic>P<\/jats:italic> = 0.001), WHO classification (<jats:italic>P<\/jats:italic>=0.001), high expression of p53 (<jats:italic>P<\/jats:italic>=0.03), and low expression of p21 (<jats:italic>P<\/jats:italic>=0.02) and p27 (<jats:italic>P<\/jats:italic>=0.001) were found to be correlated with a reduced disease\u2010free survival. Low p27 expression was found to be the most significant predictive factor of a short disease\u2010free survival (<jats:italic>P<\/jats:italic>=0.001), especially when associated with low p21 expression and high p53 expression (<jats:italic>P<\/jats:italic>=0.0001).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>Long\u2010term disease\u2010free survival in thymoma patients treated with radical surgical resection was found to be correlated with Masaoka stage, WHO classification, and expression of cell\u2010cycle proteins, with the latter found to be the most significant predictive factor. Functional cooperation between cell\u2010cycle proteins might constitute another level of regulation in tumor growth. More careful surveillance should be adopted whenever there is negative cell\u2010cycle protein expression. Cancer 2005. \u00a9 2005 American Cancer Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.21433","type":"journal-article","created":{"date-parts":[[2005,10,4]],"date-time":"2005-10-04T17:47:09Z","timestamp":1128448029000},"page":"2063-2071","source":"Crossref","is-referenced-by-count":27,"title":["Long\u2010term disease\u2010free survival of patients with radically resected thymomas"],"prefix":"10.1002","volume":"104","author":[{"given":"Tommaso","family":"Claudio Mineo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincenzo","family":"Ambrogi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Davide","family":"Mineo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfonso","family":"Baldi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,10,4]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199910000-00012"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-4975(91)90478-9"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-4975(95)00669-C"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(96)70265-9"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19811201)48:11<2485::AID-CNCR2820481123>3.0.CO;2-R"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/1010-7940(94)90155-4"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19940715)74:2<542::AID-CNCR2820740203>3.0.CO;2-1"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(00)01140-1"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(03)00798-0"},{"key":"e_1_2_6_11_2","series-title":"Atlas of tumor pathology, 2nd series","first-page":"1","volume-title":"Fascicle 13","author":"Rosai J","year":"1976"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(20)31934-6"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00737071"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/112.3.304"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/112.3.308"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/112.3.299"},{"key":"e_1_2_6_17_2","first-page":"1","volume-title":"International histological classification of tumors","author":"Rosai J","year":"1999"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.10665"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2003.07.042"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.10.113"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.10373"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(03)00819-1"},{"key":"e_1_2_6_23_2","first-page":"3708","article-title":"Correlating genetic aberrations with World Health Organization\u2010defined histology and stage across the spectrum of thymomas","volume":"63","author":"Inoue M","year":"2003","journal-title":"Cancer Res."},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.274.5293.1672"},{"key":"e_1_2_6_25_2","first-page":"211","article-title":"Cell cycle control in mammalian cells: role of cyclins, cyclin dependent kinases (CDKs), growth suppressor genes and cyclin\u2010dependent kinase inhibitors","volume":"11","author":"Grana X","year":"1995","journal-title":"Oncogene."},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1998.16.9.3158"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.57.1.58"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(10)62558-1"},{"key":"e_1_2_6_29_2","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/S1052-3359(25)00581-2","article-title":"The radiotherapeutic management of invasive thymomas","volume":"11","author":"Dziuba SJ","year":"2001","journal-title":"Chest Surg Clin N Am."},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(02)03828-6"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.10226"}],"container-title":["Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcncr.21433","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cncr.21433","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T19:30:52Z","timestamp":1760297452000},"score":1,"resource":{"primary":{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/10.1002\/cncr.21433"}},"subtitle":["Relevance of cell\u2010cycle protein expression"],"short-title":[],"issued":{"date-parts":[[2005,10,4]]},"references-count":30,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2005,11,15]]}},"alternative-id":["10.1002\/cncr.21433"],"URL":"https:\/\/doi.org\/10.1002\/cncr.21433","archive":["Portico"],"relation":{},"ISSN":["0008-543X","1097-0142"],"issn-type":[{"type":"print","value":"0008-543X"},{"type":"electronic","value":"1097-0142"}],"subject":[],"published":{"date-parts":[[2005,10,4]]}}}