{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T03:02:30Z","timestamp":1775012550619,"version":"3.50.1"},"reference-count":48,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2005,10,12]],"date-time":"2005-10-12T00:00:00Z","timestamp":1129075200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2005,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Numerous studies have examined short\u2010term and long\u2010term psychologic responses to genetic testing for breast\/ovarian carcinoma susceptibility in clinic samples and among families who participated in genetic linkage studies. However, to the authors' knowledge, the vast majority of studies focused on non\u2010Latino whites and women. In this prospective study, the authors investigated the psychologic impact of receiving carrier\u2010specific <jats:italic>BRCA1<\/jats:italic> test results as part of a genetic education\/counseling intervention in female and male members of an African\u2010American kindred with a <jats:italic>BRCA1<\/jats:italic> mutation.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Eighty\u2010five of 101 participating kindred members (84%) underwent genetic counseling\/education and testing according to an established protocol. Participants completed in\u2010person or telephone\u2010administered, computer\u2010assisted interviews. At baseline and after the receipt of test results (1 mo, 4 mos, and 12 mos), general psychologic distress (i.e., anxiety and depression) and cancer\u2010specific distress were measured. Statistical analyses were performed using linear mixed\u2010model approaches for longitudinal data.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>The hypothesis that mutation carriers, particularly women who had no personal history of breast carcinoma, were expected to report greater distress than noncarriers was not supported. After controlling for socioeconomic status and personal history of breast\/ovarian carcinoma, noncarriers reported significant declines in the distress measures (depressive symptoms, anxiety and cancer\u2010related worries), whereas distress was not altered markedly in carriers after genetic risk notification.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>The current findings suggested that individuals receiving <jats:italic>BRCA1<\/jats:italic> test results who learn that they are not carriers of a deleterious mutation may experience psychologic benefits. Furthermore, those who learned that they were mutation carriers did not appear to have adverse, clinically meaningful psychologic outcomes. Cancer 2005. \u00a9 2005 American Cancer Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.21479","type":"journal-article","created":{"date-parts":[[2005,10,12]],"date-time":"2005-10-12T16:46:52Z","timestamp":1129135612000},"page":"2508-2516","source":"Crossref","is-referenced-by-count":30,"title":["The impact of receiving genetic test results on general and cancer\u2010specific psychologic distress among members of an African\u2010American kindred with a <i>BRCA1<\/i> mutation"],"prefix":"10.1002","volume":"104","author":[{"given":"Anita Yeomans","family":"Kinney","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lindsey E.","family":"Bloor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diptasri","family":"Mandal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara 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