{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T10:37:21Z","timestamp":1790246241049,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,12,30]],"date-time":"2005-12-30T00:00:00Z","timestamp":1135900800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2006,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Prostate carcinoma (PCa) is one of the most common malignancies in men. Androgen\u2010deprivation therapy (ADT) is used frequently in the treatment of recurrent and metastatic PCa, rendering these men hypogonadal. Because male hypogonadism is associated with an unfavorable metabolic profile, and men with PCa have high cardiovascular mortality, the authors evaluated the effects of long\u2010term ADT on fasting glucose levels, insulin levels, and insulin resistance.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>To evaluate the long\u2010term effects of ADT on fasting glucose and insulin resistance in men with PCa who received ADT and to determine whether these metabolic alterations are a result of hypogonadism, the authors conducted a cross\u2010sectional study at a university\u2010based research institution in the United States. In total, 53 men were evaluated, including 18 men with PCa who received ADT for at least 12 months prior to the onset of the study (the ADT group), 17 age\u2010matched men with nonmetastatic PCa who had undergone prostatectomy and\/or received radiotherapy and who were not receiving ADT (the non\u2010ADT group), and 18 age\u2010matched controls (the control group). None of the men had a known history of diabetes mellitus.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>The mean age was similar in all 3 groups (<jats:italic>P<\/jats:italic> = 0.33). Serum total testosterone levels (<jats:italic>P<\/jats:italic> &lt; 0.0001) and free testosterone levels (<jats:italic>P<\/jats:italic> &lt; 0.0001) were significantly lower in the ADT group compared with the other groups. Men in the ADT group had a higher BMI compared with the other groups (overall <jats:italic>P<\/jats:italic> = 0.005). After adjustment for age and BMI, men in the ADT group had significantly higher fasting levels of the following parameters: 1) Glucose levels were 131.0 \u00b1 7.43 mg\/dL in the ADT group compared with 103.0 \u00b1 7.42 mg\/dL in the non\u2010ADT group (<jats:italic>P<\/jats:italic> = 0.01) and 99.0 \u00b1 7.58 mg\/dL in the control group (<jats:italic>P<\/jats:italic> &lt; 0.01). 2) Insulin levels were 45.0 \u00b1 7.25 uU\/mL in the ADT group compared with 24.0 \u00b1 7.24 uU\/mL in the non\u2010ADT group (<jats:italic>P<\/jats:italic> = 0.05) and 19.0 \u00b1 7.39 uU\/mL in the control group (<jats:italic>P<\/jats:italic> = 0.02). 3) Leptin levels were 25.0 \u00b1 2.57 ng\/mL in the ADT group compared with 12.0 \u00b1 2.56 ng\/mL in the non\u2010ADT group (<jats:italic>P<\/jats:italic> &lt; 0.01) and 6.0 \u00b1 2.62 ng\/mL in the control group (<jats:italic>P<\/jats:italic> &lt; 0.01). 4) The homeostatic model assessment for insulin resistance (HOMA<jats:sub>IR<\/jats:sub>) = 17.0 \u00b1 2.78 in the ADT group compared with HOMA<jats:sub>IR<\/jats:sub> = 6.0 \u00b1 2.77 in the non\u2010ADT group (<jats:italic>P<\/jats:italic> &lt; 0.01) and HOMA<jats:sub>IR<\/jats:sub> = 5.0 \u00b1 2.83 in the control group (<jats:italic>P<\/jats:italic> = 0.01). There was a significant negative correlation between total and free testosterone levels with fasting glucose, insulin, leptin, and HOMA<jats:sub>IR<\/jats:sub>.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>The current data suggested that men with PCa who are receiving long\u2010term ADT are at risk for developing insulin resistance and hyperglycemia, thus leading to their increased risk of cardiovascular disease. This adverse metabolic profile developed independent of age and BMI and appeared to be a direct result of androgen deprivation. Cancer 2006. \u00a9 2005 American Cancer Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.21642","type":"journal-article","created":{"date-parts":[[2005,12,30]],"date-time":"2005-12-30T17:46:31Z","timestamp":1135964791000},"page":"581-588","source":"Crossref","is-referenced-by-count":318,"title":["Hyperglycemia and insulin resistance in men with prostate carcinoma who receive androgen\u2010deprivation therapy"],"prefix":"10.1002","volume":"106","author":[{"given":"Shehzad","family":"Basaria","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis C.","family":"Muller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael A.","family":"Carducci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josephine","family":"Egan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian 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