{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:42:22Z","timestamp":1791297742769,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2006,2,8]],"date-time":"2006-02-08T00:00:00Z","timestamp":1139356800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health Grant","doi-asserted-by":"crossref","award":["5R25-CA089017-03"],"award-info":[{"award-number":["5R25-CA089017-03"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Brain Science Foundation, Boston, Massachusetts"},{"name":"Goldfine family"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2006,3,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Detailed population\u2010based estimates of long\u2010term survival as well as patterns of care for patients with low\u2010grade gliomas examined by age at diagnosis, gender, and race have not been widely available.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Time to death was examined among 2009 individuals diagnosed with a supratentorial low\u2010grade glioma and reported to the Surveillance, Epidemiology, and End Results (SEER) program of the National Cancer Institute from 1973\u20132001 using Kaplan\u2013Meier estimation. A Cox proportional hazards model was used to assess the effect of age at diagnosis, race, gender, histology, anatomic location within the brain, first course of treatment, and year of diagnosis upon this risk.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>The cumulative 5\u2010, 10\u2010, 15\u2010 and 20\u2010year survival rates among all individuals initially diagnosed with a supratentorial low\u2010grade glioma were 59.9% (95% confidence interval [95% CI], 57.6\u201362.2); 42.6% (95% CI, 39.9\u201345.2); 31.9% (95% CI, 29.0\u201334.8); and 26.0% (95% CI, 22.7\u201329.2), respectively. Improved survival was significantly associated with female gender (hazard ratio [HR], 0.84; 95% CI, 0.74\u20130.95), younger age, white race (HR, 0.70; 95% CI, 0.54\u20130.93), histology, and later year of diagnosis. Surgical treatment was associated with increased survival. The use of radiation therapy as a first course of treatment for these lesions has significantly decreased over time with the majority of patients receiving only surgery as a first course of treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>Data for patients diagnosed with low\u2010grade gliomas revealed increasing survival times over the past 25 years with a subset of patients surviving for decades. Differences in survival by race, gender, histology, and first course of treatment were appreciated. These data suggested that the clinical course of low\u2010grade glioma for some patients may be more encouraging than previously perceived and that the identification of this group of patients may allow refinement of current treatment protocols. Cancer 2006. \u00a9 2006 American Cancer Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.21733","type":"journal-article","created":{"date-parts":[[2006,2,9]],"date-time":"2006-02-09T16:28:22Z","timestamp":1139502502000},"page":"1358-1363","source":"Crossref","is-referenced-by-count":197,"title":["Survival rates and patterns of care for patients diagnosed with supratentorial low\u2010grade gliomas"],"prefix":"10.1002","volume":"106","author":[{"given":"Elizabeth B.","family":"Claus","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter M.","family":"Black","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,2,8]]},"reference":[{"key":"e_1_2_5_2_2","unstructured":"Central Brain Tumor Registry ofthe United States (CBTRUS). 2002 tables. Available at URL:http:\/\/www.cbtrus.org\/2002tables2002_18.htm[accessed January 28 2004]."},{"key":"e_1_2_5_3_2","unstructured":"SEER Public\u2010Use 1973\u20132001. Surveillance Epidemiology and End Results (SEER) Program Public Use Data (1973\u20132001) National Cancer Institute DCCPS Surveillance Research Program Cancer Statistics Branch."},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1998.88.1.0001"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19990115)85:2<485::AID-CNCR29>3.0.CO;2-L"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.54.7.1442"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s007010050241"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006123-199605000-00002"},{"key":"e_1_2_5_9_2","first-page":"153","article-title":"Brain tumor survival: results from the National Cancer Data Base","volume":"40","author":"Surawicz TS","year":"1998","journal-title":"Neuro\u2010oncol."},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/1.3.205"},{"key":"e_1_2_5_11_2","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/j.2517-6161.1972.tb00899.x","article-title":"Regression models and life tables","volume":"34","author":"Cox DR","year":"1972","journal-title":"J R Stat Soc[B]."},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.3790\/978-3-428-06689-6"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1159\/000073980"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/90.19.1473"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/00019052-200412000-00006"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2001.95.5.0735"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20867"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006123-199909000-00001"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1054\/jocn.2000.0833"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/0090-3019(95)00184-0"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19900701)66:1<6::AID-CNCR2820660103>3.0.CO;2-F"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.61.3.291"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1005715703598"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-7091-6043-5_9"},{"key":"e_1_2_5_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(90)90397-3"},{"key":"e_1_2_5_26_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa043331"},{"key":"e_1_2_5_27_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-03-0053"}],"container-title":["Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcncr.21733","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cncr.21733","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T15:26:07Z","timestamp":1760282767000},"score":1,"resource":{"primary":{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/10.1002\/cncr.21733"}},"subtitle":["Data from the SEER program, 1973\u20132001"],"short-title":[],"issued":{"date-parts":[[2006,2,8]]},"references-count":26,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2006,3,15]]}},"alternative-id":["10.1002\/cncr.21733"],"URL":"https:\/\/doi.org\/10.1002\/cncr.21733","archive":["Portico"],"relation":{},"ISSN":["0008-543X","1097-0142"],"issn-type":[{"value":"0008-543X","type":"print"},{"value":"1097-0142","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,2,8]]}}}