{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T07:59:43Z","timestamp":1789459183996,"version":"build-2803163510"},"reference-count":59,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2006,5,10]],"date-time":"2006-05-10T00:00:00Z","timestamp":1147219200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2006,6,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Patients with cancer often develop anorexia, fatigue, and decreased muscle mass. These signs and symptoms are nonspecific, and they frequently occur in other conditions, including hypogonadism.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>The objectives of this study were 1) to measure testosterone levels in patients with cancer and 2) to examine the correlations between testosterone, tumor necrosis factor\u2010\u03b1 (TNF\u2010\u03b1), interleukin\u20106 (IL\u20106), insulin\u2010like growth factor\u20101 (IGF\u20101), ghrelin levels, and appetite in patients with cancer patients and in a noncancer control group. This was designed as a cross\u2010sectional study in the setting of a university\u2010affiliated Veterans Affairs Medical Center. The study population included 31 male patients with cancer and 25 gender\u2010matched noncancer controls of similar age. The variables total testosterone (TT), calculated free testosterone (cFT), calculated bioavailable testosterone (cBT), sex hormone\u2010binding globulin (SHBG), luteinizing hormone (LH), TNF\u2010\u03b1, IL\u20106, IGF\u20101, and active ghrelin were measured in fasting morning plasma samples. Appetite was measured according to a visual analog scale. The main outcome measures were cFT and cBT.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Cancer patients had mean TT levels similar to levels in the noncancer control group but significantly lower levels of cFT, cBT, IGF\u20101, and appetite. SHBG, LH, TNF\u2010\u03b1, IL\u20106, and ghrelin levels were increased in patients with cancer compared with the control group. cFT and cBT levels were correlated inversely with IL\u20106 and ghrelin levels and were correlated directly with IGF\u20101 levels and appetite.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>Patients with cancer had lower levels of biologically active testosterone. TT was not adequate for the evaluation of hypogonadism, because SHBG levels were increased. A reliable measurement of FT and\/or BT should be used. LH was elevated in the patients with cancer, indicating that low FT levels were caused by primary testicular dysfunction. The authors postulated that high IL\u20106 or ghrelin levels inhibit testosterone synthesis, although a secondary effect at the hypothalamic\u2010pituitary levels cannot be excluded. Cancer 2006. \u00a9 2006 American Cancer Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.21889","type":"journal-article","created":{"date-parts":[[2006,5,10]],"date-time":"2006-05-10T19:12:01Z","timestamp":1147288321000},"page":"2583-2591","source":"Crossref","is-referenced-by-count":86,"title":["Hypogonadism in male patients with cancer"],"prefix":"10.1002","volume":"106","author":[{"given":"Jose M.","family":"Garcia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiling","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas","family":"Mann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Epner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa G.","family":"Hayes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Marcelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glenn R.","family":"Cunningham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,5,10]]},"reference":[{"key":"e_1_2_5_2_2","first-page":"873","article-title":"Association between malnutrition and caloric intake, emesis, psychological depression, glucose taste, and tumor mass","volume":"68","author":"Bruera E","year":"1984","journal-title":"Cancer Treat Rep."},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0885-3924(94)00077-X"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2004.10.003"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1703421"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-8049(00)00291-4"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-8588(02)00011-4"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.med.56.082103.104518"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.61.2.162"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-1788"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc927"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.11178"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1159\/000079408"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(02)00230-9"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2002.021022"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1089\/107999099312948"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.2002.01540.x"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.80.7.2082"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.83.6.1886"},{"issue":"5","key":"e_1_2_5_20_2","first-page":"E820","article-title":"Testosterone administration to elderly men increases skeletal muscle strength and protein synthesis","volume":"269","author":"Urban RJ","year":"1995","journal-title":"Am J Physiol."},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/45230"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1210\/edrv.18.5.0316"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.85.12.7167"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.86.12.8111"},{"key":"e_1_2_5_25_2","first-page":"774","article-title":"Increased plasma ghrelin level in lung cancer cachexia","volume":"9","author":"Shimizu Y","year":"2003","journal-title":"Clin Cancer Res."},{"key":"e_1_2_5_26_2","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2001.5854"},{"key":"e_1_2_5_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2004.03.003"},{"issue":"9","key":"e_1_2_5_28_2","first-page":"1","article-title":"Management of cancer pain: adults. 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