{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T03:49:32Z","timestamp":1776829772199,"version":"3.51.2"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,5,23]],"date-time":"2006-05-23T00:00:00Z","timestamp":1148342400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2006,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Fluorine\u201018 fluoro\u2010deoxyglucose positron emission tomography (FDG\u2010PET) scanning has excellent sensitivity and specificity for staging non\u2010Hodgkin lymphomas, but to the authors' knowledge few studies to date have evaluated FDG\u2010PET in low\u2010grade lymphomas only.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>A retrospective study was performed on patients with biopsy\u2010proven nontransformed and transformed follicular lymphoma (FL), B\u2010cell small\u2010cell lymphocytic lymphoma (SLL\/CLL), or marginal zone lymphoma (MZL) who underwent PET and computed tomography (CT) scans within 3 weeks. Standard uptake values (SUV) of all abnormal foci were measured.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>In FL, PET demonstrated 94% sensitivity and 100% specificity for staging. PET was more specific than CT for detecting recurrence or assessing therapeutic responses (91% vs. 50%). FDG avidity among patients with WHO Grades 1, 2, and 3 disease was not significantly different (analysis of variance [ANOVA]). For MZL staging, PET had moderate sensitivity (71%) and outperformed CT alone in the depiction of extranodal sites (85% vs. 57% sensitivity). In SLL\/CLL, PET sensitivity was 53% and underestimated disease extent in 5 of 19 patients (26%) compared with CT. PET did not affect initial management but confirmed suspected recurrences in 75% of patients. Nontransformed FL had a higher SUV (ANOVA, <jats:italic>P<\/jats:italic>&lt;.05) compared with MZL and SLL\/CLL. SUV was higher in transformed than in nontransformed tumors (<jats:italic>P<\/jats:italic>&lt;.001, Student <jats:italic>t<\/jats:italic> test).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>PET usefulness in staging low\u2010grade lymphomas varies depending on histology. PET sensitivity is excellent in FL and moderate in MZL. PET is more specific than CT for follow\u2010up in all types. PET has limited usefulness for SLL\/CLL staging. However, a suggestive pattern of hazy and mild uptake was often noted in positive scans. In all low\u2010grade lymphomas, the emergence of foci of intense uptake should raise suspicion of conversion to high\u2010grade disease. Cancer 2006. \u00a9 2006 American Cancer Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.21967","type":"journal-article","created":{"date-parts":[[2006,5,23]],"date-time":"2006-05-23T18:27:38Z","timestamp":1148408858000},"page":"175-183","source":"Crossref","is-referenced-by-count":181,"title":["Role of fluorine\u201018 fluoro\u2010deoxyglucose positron emission tomography scan in the evaluation and follow\u2010up of patients with low\u2010grade lymphomas"],"prefix":"10.1002","volume":"107","author":[{"given":"Maroun","family":"Karam","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leon","family":"Novak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jomol","family":"Cyriac","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ameera","family":"Ali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tipu","family":"Nazeer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francis","family":"Nugent","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,5,23]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rcl.2004.08.008"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2004.05069.x"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21253"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1011169332265"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.3816\/CLM.2002.n.012"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.semnuclmed.2005.02.002"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminoncol.2005.01.008"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V85.2.307.307"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.4065\/80.8.1087"},{"key":"e_1_2_6_11_2","volume-title":"World Health Organization Classification of Tumours. 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