{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T01:50:38Z","timestamp":1790819438131,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,6,15]],"date-time":"2006-06-15T00:00:00Z","timestamp":1150329600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2006,7,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND.<\/jats:title><jats:p>Enchondromas are benign lesions that can occur as solitary tumors or multiple tumors (Ollier disease) and may be precursors of central chondrosarcomas. Recurrent chondrosarcomas can be of a higher grade compared with primary tumors, suggesting possible progression.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS.<\/jats:title><jats:p>Genome\u2010wide array\u2010comparative genomic hybridization (CGH) was used to investigate copy number changes in enchondromas and central chondrosarcomas to elucidate both primary genetic events and the events related to tumor progression. Analyses of variance, Student <jats:italic>t<\/jats:italic> tests, and hierarchical clustering were used for the current analyses. Array\u2010CGH data were compared with complementary DNA (cDNA) and quantitative reverse\u2010transcriptase polymerase chain reaction expression array data.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS.<\/jats:title><jats:p>Genomic imbalances were rare in enchondromas and in grade I chondrosarcomas, whereas they were frequent in high\u2010grade tumors. No genomic imbalances that were specific for Ollier disease were found. The authors identified 22 chromosome regions that were imbalanced in \u226525% of tumors, and 3 of those regions were located on chromosome 12 (12p13, 12p11.21\u2010p11.23, and 12q13, containing among others the PTPRF\u2010interacting protein\u2010binding protein 1 (<jats:italic>PPFIBP1<\/jats:italic>) gene. Loss of chromosome 6 and gain of 12q12 were associated with higher grade. Comparison of array\u2010CGH with cDNA expression showed correlations for the ribosomal protein S6 (<jats:italic>RPS6<\/jats:italic>) and cyclin\u2010dependent kinase 4 (<jats:italic>CDK4<\/jats:italic>) genes.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS.<\/jats:title><jats:p>In the current study the authors identified genomic regions and new candidate genes (<jats:italic>RPS6<\/jats:italic>, <jats:italic>CDK4<\/jats:italic>, and <jats:italic>PPFIBP1<\/jats:italic>) that were associated with tumor progression and prognosis in patients with high\u2010grade chondrosarcomas. Cancer 2006. \u00a9 2006 American Cancer Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.22001","type":"journal-article","created":{"date-parts":[[2006,6,15]],"date-time":"2006-06-15T12:13:20Z","timestamp":1150373600000},"page":"380-388","source":"Crossref","is-referenced-by-count":49,"title":["Array\u2010comparative genomic hybridization of central chondrosarcoma"],"prefix":"10.1002","volume":"107","author":[{"given":"Leida B.","family":"Rozeman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karoly","family":"Szuhai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvonne M.","family":"Schrage","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla","family":"Rosenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans J.","family":"Tanke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonie H. M.","family":"Taminiau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne Marie","family":"Cleton\u2010Jansen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith V. M. G.","family":"Bov\u00e9e","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pancras C. W.","family":"Hogendoorn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,5]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"247","volume-title":"World Health Organisation classification of tumours. 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