{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T00:42:51Z","timestamp":1770684171352,"version":"3.49.0"},"reference-count":46,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,6,13]],"date-time":"2006-06-13T00:00:00Z","timestamp":1150156800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2006,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND.<\/jats:title><jats:p>Obesity and prostate cancer are among the most common health problems affecting American men today. The authors' goal was to assess the impact of obesity on clinical and pathologic features of prostate cancer and long\u2010term outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS.<\/jats:title><jats:p>The authors performed a prospective cohort study on 5313 men who underwent radical prostatectomy between 1990 and 1999. Patient height and weight were measured at the time of surgery to calculate the body mass index (BMI). The patients were separated into 3 BMI groups: BMI &lt;25, 25\u201329.9, and \u226530 kg\/m<jats:sup>2<\/jats:sup>. The associations between BMI and age, prostate\u2010specific antigen (PSA) level, and Gleason score were assessed with the Spearman rank correlation test. The associations between BMI and pathologic features were assessed with the Mantel\u2013Haenszel \u03c7<jats:sup>2<\/jats:sup> test. Fifteen\u2010year biochemical progression\u2010free survival, systemic progression\u2010free survival, cancer\u2010specific survival, and overall survival were estimated using the Kaplan\u2013Meier method and evaluated using Cox models.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS.<\/jats:title><jats:p>The median length of follow\u2010up for the entire cohort was 10.1 years. Clinical and pathologic features appear worse in patients with a higher BMI. On univariate and multivariate analyses, it was found that BMI had no impact on biochemical progression, systemic progression, prostate cancer survival, or overall survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS.<\/jats:title><jats:p>Obese patients appear to have worse pathologic features at the time of prostatectomy. Despite these features, long\u2010term oncologic outcomes, including cancer\u2010specific survival, remain the same regardless of BMI. BMI appears to influence prostate cancer outcomes at the time of prostatectomy, as evidenced by more aggressive pathologic features. However, after prostatectomy, BMI does not appear to be an independent predictor of recurrence or survival. Cancer 2006. \u00a9 2006 American Cancer Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.22030","type":"journal-article","created":{"date-parts":[[2006,6,13]],"date-time":"2006-06-13T12:32:07Z","timestamp":1150201927000},"page":"521-529","source":"Crossref","is-referenced-by-count":106,"title":["Obesity and survival after radical prostatectomy: A 10\u2010year prospective cohort study"],"prefix":"10.1002","volume":"107","author":[{"given":"Sameer A.","family":"Siddiqui","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brant A.","family":"Inman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shomik","family":"Sengupta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey M.","family":"Slezak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric J.","family":"Bergstralh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bradley C.","family":"Leibovich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Horst","family":"Zincke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael L.","family":"Blute","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,18]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.291.23.2847"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djg009"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6602819"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa021423"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/89.5.385"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.04.181"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.03.132"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-04-1977"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-04-2257"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20991"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000169459.78982.d7"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000091876.13656.2e"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22279"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)67457-5"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(99)00252-6"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.4065\/70.12.1137"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01008010"},{"key":"e_1_2_5_19_2","volume-title":"AJCC Cancer Staging Manual","author":"Fleming ID","year":"1998"},{"key":"e_1_2_5_20_2","first-page":"125","article-title":"Classification of prostatic carcinomas","volume":"50","author":"Gleason DF","year":"1966","journal-title":"Cancer Chemother Rep."},{"key":"e_1_2_5_21_2","first-page":"51S","article-title":"Clinical guidelines on the identification, evaluation, and treatment of overweight and obesity in adults\u2013\u2013The evidence report. 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