{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T00:31:45Z","timestamp":1760315505080,"version":"build-2065373602"},"reference-count":43,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2006,8,7]],"date-time":"2006-08-07T00:00:00Z","timestamp":1154908800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2006,9,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>The transcription factor avian erythroblastosis virus E26 (V\u2010Ets) oncogene homolog 1 (Ets\u20101) is involved in tumor development and progression through the transcriptional regulation of several matrix\u2010degrading enzyme systems, including matrix metalloproteinases (MMPs). It has been demonstrated that the MMPs are expressed strongly in high\u2010grade meningiomas. To determine the biologic significance of Ets\u20101 in the progression of benign meningiomas, the authors investigated the expressions of Ets\u20101 and its target genes MMP\u20102 and MMP\u20109 in primary and recurrent, Grade 1 meningiomas.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>The expression levels of Ets\u20101, MMP\u20102, and MMP\u20109 were examined by immunohistochemistry in 70 Grade 1 meningiomas, including 36 primary tumors without recurrence after 5 years of follow\u2010up and 17 pairs of primary tumors and subsequent recurrences.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>The results demonstrated higher expression of Ets\u20101, MMP\u20102, and MMP\u20109 proteins in meningiomas with subsequent recurrences compared with meningiomas from patients who had no recurrences (<jats:italic>P<\/jats:italic> &lt; .001). In addition, Ets\u20101 expression was correlated with the expression of both MMP\u20102 and MMP\u20109.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>Ets\u20101 may be involved in meningioma recurrence by up\u2010regulating MMP\u20102 and MMP\u20109. Increased expression of these genes in World Health Organization grade 1 meningiomas may serve as an indicator for a high risk of recurrence. Cancer 2006. \u00a9 2006 American Cancer Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.22130","type":"journal-article","created":{"date-parts":[[2006,8,7]],"date-time":"2006-08-07T11:19:57Z","timestamp":1154949597000},"page":"1365-1372","source":"Crossref","is-referenced-by-count":25,"title":["Increased expression of avian erythroblastosis virus E26 oncogene homolog 1 in World Health Organization grade 1 meningiomas is associated with an elevated risk of recurrence and is correlated with the expression of its target genes matrix metalloproteinase\u20102 and MMP\u20109"],"prefix":"10.1002","volume":"107","author":[{"given":"Ali Fuat","family":"Okuducu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrich","family":"Zils","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silke A. M.","family":"Michaelis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Mawrin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"von Deimling","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,9]]},"reference":[{"key":"e_1_2_5_2_2","first-page":"174","volume-title":"World Health Organization Classification of Tumours. 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