{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T15:34:06Z","timestamp":1772552046768,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2006,9,18]],"date-time":"2006-09-18T00:00:00Z","timestamp":1158537600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2006,10,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND.<\/jats:title><jats:p>Inhibitor of apoptosis proteins (IAPs) inhibit apoptosis by binding specific caspases, and possibly by other mechanisms. Eight IAPs have been identified in humans, of which cIAP1, cIAP2, and XIAP are well known. IAPs are being investigated as potential treatment targets in cancer patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS.<\/jats:title><jats:p>cIAP1, cIAP2, and XIAP were assessed in lymphoma cell lines, 240 B\u2010cell non\u2010Hodgkin lymphoma (NHL) tumors, and 40 Hodgkin lymphoma (HL) tumors.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS.<\/jats:title><jats:p>All IAPs were expressed in most NHL and all HL cell lines. In NHL tumors, cIAP1 was expressed in 174 (73%), cIAP2 in 115 (48%), and XIAP in 37 (15%). cIAP1 was positive in all precursor B\u2010cell lymphoblastic lymphoma\/leukemia (LBL) and nodal marginal zone B\u2010cell lymphoma (MZL), over 90% of follicular lymphoma and diffuse large B\u2010cell lymphoma (DLBCL), and approximately 50% to 60% of myeloma, Burkitt lymphoma (BL), lymphoplasmacytic lymphoma\/Waldenstrom macroglobulinemia (LPL\/WM), small lymphocytic lymphoma\/ chronic lymphocytic leukemia (SLL\/CLL), extranodal marginal zone B\u2010cell lymphoma of mucosa associated lymphoid tissue (MALT\u2010lymphoma), splenic MZL, and mantle cell lymphoma. cIAP2 was positive in all MALT\u2010lymphoma, over 90% of precursor B\u2010cell LBL (94%), most BL (75%), LPL\/WM (71%), and SLL\/CLL (67%), and approximately 40% to 60% of follicular lymphoma, myeloma, and DLBCL. XIAP was positive most cases of precursor B\u2010cell LBL (57%) and approximately 30% to 40% of nodal MZL, BL, and DLBCL. In HL tumors, cIAP1 was positive in 30 (75%), cIAP2 in 27 (68%), and XIAP in 23 (58%), and did not correlate with histologic type.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS.<\/jats:title><jats:p>Differential expression of IAPs in B\u2010cell lymphomas suggests differences in pathogenesis that may have implications for novel treatment strategies targeting IAPs. Cancer 2006. \u00a9 2006 American Cancer Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.22219","type":"journal-article","created":{"date-parts":[[2006,9,18]],"date-time":"2006-09-18T21:24:58Z","timestamp":1158614698000},"page":"1844-1851","source":"Crossref","is-referenced-by-count":45,"title":["Expression of inhibitor of apoptosis proteins in B\u2010cell non\u2010Hodgkin and Hodgkin lymphomas"],"prefix":"10.1002","volume":"107","author":[{"given":"Nalan","family":"Akyurek","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongsheng","family":"Ren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georgios Z.","family":"Rassidakis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ellen J.","family":"Schlette","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. 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