{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T04:05:07Z","timestamp":1792641907887,"version":"4.5.0"},"reference-count":14,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2006,10,24]],"date-time":"2006-10-24T00:00:00Z","timestamp":1161648000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2006,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND.<\/jats:title><jats:p>Early diagnosis of recurrent breast cancer is crucial to selection of the most appropriate therapy. The current study evaluated the role of FDG\u2010PET\/CT in the assessment of suspected recurrent breast cancer in patients who presented with elevated serum tumor markers.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS.<\/jats:title><jats:p>Forty\u2010seven consecutive FDG\u2010PET\/CT studies of 46 women (aged 32\u201379 years; mean, 59.9 years) with a history of breast cancer presented with elevated serum tumor markers 1\u201321 years (mean = 6.2 years) after their initial diagnosis and were retrospectively evaluated. PET\/CT results were confirmed by pathology (n = 11), further imaging, and follow\u2010up (mean = 17.2 months; n = 36). Changes in further management based on PET\/CT were recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS.<\/jats:title><jats:p>Thirty (65%) patients had tumor recurrence, and 16 (35%) patients showed no further evidence of disease. Thirty\u2010one patients had 32 abnormal PET\/CT studies, and 15 patients had normal studies with an overall sensitivity, specificity, and accuracy of 90%, 71%, and 83%, respectively. In 37 patients, PET\/CT was compared with contrast\u2010enhanced CT and had a higher sensitivity (85% vs 70%), specificity (76% vs 47%), and accuracy (81% vs 59%). PET\/CT had an impact on the management of 24 (5l%) patients. Of these, chemotherapy or radiotherapy was started in 16 patients, treatment was modified in 2 patients, and 6 patients were referred to biopsy, followed by referral to surgery for 2 patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS.<\/jats:title><jats:p>In patients with breast cancer and rising tumor markers, FDG\u2010PET\/CT had high performance indices and was superior to CT for diagnosis of tumor recurrence, which led to changes in the subsequent clinical management of 51% of these patients. Cancer 2006. \u00a9 2006 American Cancer Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.22292","type":"journal-article","created":{"date-parts":[[2006,10,24]],"date-time":"2006-10-24T21:23:43Z","timestamp":1161725023000},"page":"2545-2551","source":"Crossref","is-referenced-by-count":119,"title":["The role of FDG\u2010PET\/CT in suspected recurrence of breast cancer"],"prefix":"10.1002","volume":"107","author":[{"given":"Lea","family":"Radan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simona","family":"Ben\u2010Haim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Bar\u2010Shalom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luda","family":"Guralnik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ora","family":"Israel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,10,24]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.11.026"},{"key":"e_1_2_5_3_2","first-page":"109","article-title":"Position of nuclear medicine modalities in the diagnostic work\u2010up of breast cancer","volume":"48","author":"Buscombe JR","year":"2004","journal-title":"Q J Nucl Med Mol Imaging."},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1075-122X.2005.21625.x"},{"issue":"1","key":"e_1_2_5_5_2","first-page":"S125","article-title":"Advantages and limitations of FDG PET in the follow\u2010up of breast cancer","volume":"31","author":"Lind P","year":"2004","journal-title":"Eur J Nucl Med Mol Imaging."},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1095-0397(01)00069-3"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.semnuclmed.2004.11.001"},{"key":"e_1_2_5_8_2","first-page":"113","article-title":"Early diagnosis of recurrent breast cancer with FDG\u2010PET in patients with progressive elevation of serum tumor markers","volume":"46","author":"Suarez M","year":"2002","journal-title":"Q J Nucl Med."},{"key":"e_1_2_5_9_2","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1097\/01.RLI.0000063983.86229.f2","article-title":"F\u201018 fluorodeoxyglucose positron\u2010emission tomography in the diagnosis of tumor recurrence and metastases in the follow\u2010up of patients with breast carcinoma: a comparison to conventional imaging","volume":"38","author":"Gallowitsch HJ","year":"2003","journal-title":"Invest Radiol."},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-005-1835-7"},{"issue":"1","key":"e_1_2_5_11_2","first-page":"S118","article-title":"FDG PET and tumour markers in the diagnosis of recurrent and metastatic breast cancer","volume":"31","author":"Siggelkow W","year":"2004","journal-title":"Eur J Nucl Med Mol Imaging."},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-004-1536-7"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11307-005-0013-4"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiographics.22.1.g02ja055"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-004-3291-7"}],"container-title":["Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcncr.22292","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cncr.22292","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T19:04:32Z","timestamp":1760295872000},"score":1,"resource":{"primary":{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/10.1002\/cncr.22292"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,10,24]]},"references-count":14,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2006,12]]}},"alternative-id":["10.1002\/cncr.22292"],"URL":"https:\/\/doi.org\/10.1002\/cncr.22292","archive":["Portico"],"relation":{},"ISSN":["0008-543X","1097-0142"],"issn-type":[{"value":"0008-543X","type":"print"},{"value":"1097-0142","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,10,24]]}}}