{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T18:13:56Z","timestamp":1792088036570,"version":"4.4.0"},"reference-count":14,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2006,10,11]],"date-time":"2006-10-11T00:00:00Z","timestamp":1160524800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2006,11,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND.<\/jats:title><jats:p>Correlations between various patient, tumor, and treatment characteristics and complications in patients undergoing combined modality treatment for primary lower extremity soft\u2010tissue sarcomas were investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS.<\/jats:title><jats:p>Using the M. D. Anderson Radiation Oncology database, the records of the subset of patients treated with combined radiation and limb\u2010sparing surgery for primary lower extremity soft\u2010tissue sarcomas were retrospectively reviewed from the years 1960 to 2003.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS.<\/jats:title><jats:p>In all, 412 patients were identified. With a median follow\u2010up of 9.3 years, there were a total of 113 (27%) acute wound complications and 41 (13% at 20 years) chronic radiation\u2010related limb complications. Preoperative radiation and tumor sizes &gt;5 cm were associated with an increased risk of acute wound complications (34% preoperative vs. 16% postoperative, <jats:italic>P<\/jats:italic> &lt; .001; and 31% &gt;5 cm vs. 17% \u22645 cm, <jats:italic>P<\/jats:italic> = .005). At 20 years the radiation\u2010related complication rate was higher in patients with a groin or thigh tumor location (16% vs. 4% other; <jats:italic>P<\/jats:italic> = .008), prior acute wound complications (20% vs. 10% no surgical complication), and a radiation dose \u226560 grays (Gy) (18% vs. 9% for dose &lt; 60 Gy; <jats:italic>P<\/jats:italic> = .04). Five fractures occurred, resulting in a crude overall fracture rate of 1.2%.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS.<\/jats:title><jats:p>Patients treated with preoperative radiation for larger tumors are more likely to have acute surgical wound complications. Acute wound complications followed by postoperative radiation are associated with chronic radiation\u2010related limb problems, as are higher radiation dose and proximal tumor location. The fracture rate is so low that prophylactic fixation is not warranted. Cancer 2006. \u00a9 2006 American Cancer Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.22298","type":"journal-article","created":{"date-parts":[[2006,10,11]],"date-time":"2006-10-11T19:47:04Z","timestamp":1160596024000},"page":"2455-2461","source":"Crossref","is-referenced-by-count":182,"title":["Complications of combined modality treatment of primary lower extremity soft\u2010tissue sarcomas"],"prefix":"10.1002","volume":"107","author":[{"given":"Christopher P.","family":"Cannon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew T.","family":"Ballo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunar K.","family":"Zagars","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Attiqa N.","family":"Mirza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick P.","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerae O.","family":"Lewis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan W.","family":"Yasko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert S.","family":"Benjamin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter W.T.","family":"Pisters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,11,8]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9098(199602)61:2<90::AID-JSO2>3.0.CO;2-M"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)09292-9"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-200108000-00023"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-200502000-00012"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19980615)82:12<2356::AID-CNCR9>3.0.CO;2-Q"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2004.02.001"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(91)90337-4"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2002.03.084"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2004.12.020"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-006-9028-6"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-200204000-00022"},{"key":"e_1_2_5_13_2","volume-title":"Survivorship Analysis for Clinical Studies","author":"Harris EK","year":"1991"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002239900080"},{"key":"e_1_2_5_15_2","first-page":"27","article-title":"Bone structure and function","volume":"36","author":"Buckwalter JA","year":"1987","journal-title":"Instr Course Lect."}],"container-title":["Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcncr.22298","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cncr.22298","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T18:25:04Z","timestamp":1760293504000},"score":1,"resource":{"primary":{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/10.1002\/cncr.22298"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,11,8]]},"references-count":14,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2006,11,15]]}},"alternative-id":["10.1002\/cncr.22298"],"URL":"https:\/\/doi.org\/10.1002\/cncr.22298","archive":["Portico"],"relation":{},"ISSN":["0008-543X","1097-0142"],"issn-type":[{"value":"0008-543X","type":"print"},{"value":"1097-0142","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,11,8]]}}}