{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T06:49:41Z","timestamp":1790232581336,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2006,11,10]],"date-time":"2006-11-10T00:00:00Z","timestamp":1163116800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2006,12,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND.<\/jats:title><jats:p>The majority of gastric mucosa\u2010associated lymphoid tissue (MALT) lymphoma develops in <jats:italic>Helicobacter pylori<\/jats:italic>\u2010associated chronic gastritis. Little is still known regarding the clinicopathologic features of gastric MALT lymphoma not associated with <jats:italic>H. pylori<\/jats:italic> infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS.<\/jats:title><jats:p>One hundred thirty\u2010seven patients with gastric MALT lymphoma, in whom <jats:italic>H. pylori<\/jats:italic> status was evaluated using at least both serology and histology, were enrolled. Clinical, histopathologic, and molecular findings were compared between <jats:italic>H. pylori<\/jats:italic>\u2010negative group (n = 12; 9%) and <jats:italic>H. pylori<\/jats:italic>\u2010positive group (n = 125; 91%). t(11;18)(q21;q21) was investigated by reverse\u2010transcription polymerase chain reaction and interphase fluorescence in situ hybridization.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS.<\/jats:title><jats:p>In cases without diffuse large B\u2010cell lymphoma (DLBCL) component, <jats:italic>H. pylori<\/jats:italic>\u2010negative lymphomas located more frequently in the proximal stomach (70%), less frequently appeared as superficial type (40%), and frequently invaded the submucosa or beyond (70%). Histologically, lymphoepithelial lesions (57%), lymphoid follicles (43%), and background mucosal atrophy (50%) in the <jats:italic>H. pylori<\/jats:italic>\u2010negative group were less frequent than in the <jats:italic>H. pylori<\/jats:italic>\u2010positive group (91%, 93%, and 100%, respectively). The frequencies of t(11;18)(q21;q21) (100%) and BCL10 nuclear expression (100%) in the <jats:italic>H. pylori<\/jats:italic>\u2010negative group were significantly higher than in the <jats:italic>H. pylori<\/jats:italic>\u2010positive group (2% and 27%, respectively). Response to antibiotic treatment was observed not only in the <jats:italic>H. pylori<\/jats:italic>\u2010positive group (75%), but also in the <jats:italic>H. pylori<\/jats:italic>\u2010negative group (2 of 7 patients, 29%). In cases with a DLBCL component, such differences were not observed between the 2 groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS.<\/jats:title><jats:p><jats:italic>H. pylori<\/jats:italic>\u2010negative gastric MALT lymphoma is characterized by frequent t(11;18)(q21;q21). Antibiotic treatment should be considered also for this disease, although cases with t(11;18)(q21;q21) may need additional strategies. Cancer 2006. \u00a9 2006 American Cancer Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.22326","type":"journal-article","created":{"date-parts":[[2006,11,10]],"date-time":"2006-11-10T12:16:41Z","timestamp":1163161001000},"page":"2770-2778","source":"Crossref","is-referenced-by-count":58,"title":["<i>Helicobacter pylori<\/i>\u2010negative gastric mucosa\u2010associated lymphoid tissue lymphoma"],"prefix":"10.1002","volume":"107","author":[{"given":"Shotaro","family":"Nakamura","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takayuki","family":"Matsumoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongtao","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeo","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Suekane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Matsumoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masazumi","family":"Tsuneyoshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming\u2010Qing","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuo","family":"Iida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,12,8]]},"reference":[{"key":"e_1_2_5_2_2","first-page":"157","volume-title":"World Health Organization classification of tumours. 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