{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T16:35:04Z","timestamp":1791650104867,"version":"4.3.4"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,11,27]],"date-time":"2006-11-27T00:00:00Z","timestamp":1164585600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2007,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND.<\/jats:title><jats:p>Previous studies have shown cognitive impairment in breast cancer survivors who were exposed to adjuvant chemotherapy. Neural damage by chemotherapy might have played some part in these findings. The current study explored the regional brain volume difference between breast cancer survivors exposed to adjuvant chemotherapy (C+) and those unexposed (C\u2212).<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS.<\/jats:title><jats:p>High\u2010resolution 1.5\u2010tesla brain magnetic resonance imaging (MRI) databases of breast cancer survivors and healthy controls were used. Brain images were preprocessed for optimal voxel\u2010based morphometry. Comparisons of gray matter and white matter were performed between the C+ and the C\u2212 groups, by using MRI scans from within 1 year (the 1\u2010year study, n = 51 and n = 55, respectively) or 3 years after their cancer surgery (the 3\u2010year study, n = 73 and n = 59, respectively). As exploratory analyses, correlation analyses were performed between indices of the Wechsler Memory Scale\u2010Revised and regional brain volume where the volume were significantly smaller. As a reference, MRI scans of cancer survivors were compared with those of healthy controls (n = 55 for the 1\u2010year study and n = 37 for the 3\u2010year study).<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS.<\/jats:title><jats:p>The C+ patients had smaller gray matter and white matter including prefrontal, parahippocampal, and cingulate gyrus, and precuneus in the 1\u2010year study. However, no difference was observed in the 3\u2010year study. The volumes of the prefrontal, parahippocampal gyrus, and precuneus were significantly correlated with indices of attention\/concentration and\/or visual memory. Comparisons with healthy controls did not show any significant differences.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS.<\/jats:title><jats:p>Adjuvant chemotherapy might have an influence on brain structure, which may account for previously observed cognitive impairments. Cancer 2007. \u00a9 2006 American Cancer Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.22368","type":"journal-article","created":{"date-parts":[[2006,11,27]],"date-time":"2006-11-27T18:48:23Z","timestamp":1164653303000},"page":"146-156","source":"Crossref","is-referenced-by-count":294,"title":["Smaller regional volumes of brain gray and white matter demonstrated in breast cancer survivors exposed to adjuvant 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