{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T12:46:46Z","timestamp":1762865206058,"version":"build-2065373602"},"reference-count":44,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,12,7]],"date-time":"2006-12-07T00:00:00Z","timestamp":1165449600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2007,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND.<\/jats:title><jats:p>Microsatellite studies in histologic types B3 and C thymic neoplasia detected gains on chromosome 17q, which contains the Her\u20102\/<jats:italic>neu<\/jats:italic> and its juxtaposed topoisomerase 2\u03b1 (T2\u03b1) genes. The study aimed to evaluate their impact on tumor biology and survival of advanced thymic neoplasia patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS.<\/jats:title><jats:p>From 1991 to 2005, 36 consecutive stage IV thymic carcinoma patients were treated, 18 men and 18 women, aged 11 to 84 years. There were 22 thymic carcinoma, 13 type B3, and 1 type B2 thymoma. Patients received treatment consisting of surgical resection, combination chemotherapy with the CAP (cyclophosphamide, Adriamycin, cisplatin) regimen, or radiation therapy potentiated by high\u2010dose weekly 5\u2010fluorouracil infusion. Permutations of these 3 treatment modalities were prescribed as necessary.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS.<\/jats:title><jats:p>T2\u03b1 gene amplification was detected in 4 of 14 thymic carcinoma and 1 of 15 type B3 thymoma. Three thymic carcinoma patients had Her\u20102\/<jats:italic>neu<\/jats:italic> coamplification and these 3 patients had rapidly growing tumor and extensive disease at initial diagnosis. CAP was prescribed in 28 patients and 20 patients responded (response rate, 71.4%, 95% confidence interval [CI]: 52.8% to 85%); all responders overexpressed (\u226510% nuclei positive) the T2\u03b1 protein, whereas 4 nonresponders had very low expression. T2\u03b1 overexpression predicts CAP response, and its absence predicts resistance (<jats:italic>P<\/jats:italic> = .001). Overall survival was significantly prolonged if the tumor was resectable (<jats:italic>P<\/jats:italic> = .001), of type B3 histology (<jats:italic>P<\/jats:italic> = .0039), and had no Her\u20102 gene amplification (<jats:italic>P<\/jats:italic> = .0081).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION.<\/jats:title><jats:p>T2\u03b1 and Her\u20102\/<jats:italic>neu<\/jats:italic> genes play a pivotal role in the tumor biology, CAP response, and survival of advanced thymic neoplasia patients. Cancer 2007;109:502\u2013509. \u00a9 2006 American Cancer Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.22404","type":"journal-article","created":{"date-parts":[[2006,12,7]],"date-time":"2006-12-07T16:53:42Z","timestamp":1165510422000},"page":"502-509","source":"Crossref","is-referenced-by-count":14,"title":["Topoisomerase 2\u03b1 plays a pivotal role in the tumor biology of stage IV thymic neoplasia"],"prefix":"10.1002","volume":"109","author":[{"given":"J. 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