{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T19:24:28Z","timestamp":1774293868244,"version":"3.50.1"},"reference-count":46,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,12,18]],"date-time":"2006-12-18T00:00:00Z","timestamp":1166400000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2007,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND.<\/jats:title><jats:p>Treatments for recurrent meningiomas are limited. We previously demonstrated universal expression of COX\u20102 in meningiomas and dose\u2010dependent growth inhibition in vitro with celecoxib, a COX\u20102 inhibitor. We therefore tested the effects of celecoxib on meningioma growth in a mouse xenograft model.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS.<\/jats:title><jats:p>Meningioma cell lines (IOMM\u2010Lee, CH157\u2010MN, WHO grade I primary cultured tumor) were transplanted into flanks of nude mice fed mouse chow with celecoxib at varying concentrations (0, 500, 1000, 1500 ppm) ad libitum. Tumors were measured biweekly and processed for MIB\u20101, Factor VIII, COX\u20102, and VEGF, and assayed with transferase\u2010mediated dUTP\u2010biotin nick\u2010end labeling (TUNEL).<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS.<\/jats:title><jats:p>Celecoxib reduced growth of mean tumor volume by 66% (<jats:italic>P<\/jats:italic> &lt; .05), 25% (<jats:italic>P<\/jats:italic> &gt; .05), and 65% (<jats:italic>P<\/jats:italic> &lt; .05) compared with untreated controls in IOMM\u2010Lee, CH157\u2010MN, and benign tumors, respectively. IOMM\u2010Lee tumors removed from celecoxib treatment regained a growth rate similar to the control. Blood vessel density decreased and apoptotic cells increased in treated flank tumors. Diminished COX\u20102 expression and VEGF were observed in treated IOMM\u2010Lee tumors. Mean plasma celecoxib levels were 845, 1540, and 2869 ng\/mL, for low\u2010, medium\u2010, and high\u2010dose celecoxib, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS.<\/jats:title><jats:p>Celecoxib inhibits meningioma growth in vivo at plasma levels achievable in humans. Celecoxib\u2010treated tumors were less vascular with increased apoptosis. IOMM\u2010Lee tumors treated with celecoxib showed decreased COX\u20102 and VEGF expression. COX\u20102 inhibitors may have a role in the treatment of recurrent meningiomas. Cancer 2007;109:588\u2013597. \u00a9 2006 American Cancer Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.22441","type":"journal-article","created":{"date-parts":[[2006,12,18]],"date-time":"2006-12-18T16:30:22Z","timestamp":1166459422000},"page":"588-597","source":"Crossref","is-referenced-by-count":54,"title":["Celecoxib inhibits meningioma tumor growth in a mouse xenograft model"],"prefix":"10.1002","volume":"109","author":[{"given":"Brian T.","family":"Ragel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Randy L.","family":"Jensen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David L.","family":"Gillespie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen M.","family":"Prescott","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William 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