{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:38:13Z","timestamp":1786977493720,"version":"build-2736575974"},"reference-count":38,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T00:00:00Z","timestamp":1172016000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2007,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>Primary hepatic sarcoma is a rare entity. The objectives of the study were to define treatment and long\u2010term outcome and to identify prognostic factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>Between January 1981 and December 2004, 30 patients with primary sarcoma of the liver and 5 patients with primary carcinosarcoma of the liver were treated. Patient demographics, tumor characteristics, treatment, and actuarial survival were analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Of the 30 patients with primary hepatic sarcoma (10 epithelioid hemangioendothelioma, 5 embryonal sarcoma, 5 angiosarcoma, 3 solitary fibrous tumor, and 7 other types), 11 underwent R0\u2010resection and had a 5\u2010year disease\u2010specific survival of 64%. Of these 11 patients, 4 had low\u2010grade sarcoma and have not developed tumor recurrence. In the group of 7 patients with high\u2010grade sarcomas who underwent R0\u2010resection, both patients with angiosarcoma died within 11 months, whereas the 5 patients with embryonal sarcoma had a 5\u2010year disease\u2010free and disease\u2010specific survival of 80%. Six of the 10 patients with an epithelioid hemangioendothelioma were managed without surgery, as they had diffuse, slowly progressing, or stable lesions; these patients had a 5\u2010year disease\u2010specific survival of 67%. Of the remaining 13 patients in whom R0\u2010resection was not performed, there were no 3\u2010year survivors. The prognosis for patients with primary carcinosarcoma of the liver was poor, with all but 1 patient dying within a year and no 3\u2010year survivors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>The outcome of patients with primary hepatic sarcoma depends primarily on tumor histology and the ability to achieve complete tumor resection. Improvements in outcome will require the development of more effective systemic therapies. Cancer 2007. \u00a9 2007 American Cancer Society.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncr.22530","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T12:59:28Z","timestamp":1172062768000},"page":"1391-1396","source":"Crossref","is-referenced-by-count":154,"title":["Management of primary liver sarcomas"],"prefix":"10.1002","volume":"109","author":[{"given":"Ju\u00fcrgen","family":"Weitz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David S.","family":"Klimstra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karina","family":"Cymes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William R.","family":"Jarnagin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"D'Angelica","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael P.","family":"La Quaglia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuman","family":"Fong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murray F.","family":"Brennan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leslie H.","family":"Blumgart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald P.","family":"DeMatteo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,2,21]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197101)27:1<7::AID-CNCR2820270103>3.0.CO;2-Q"},{"key":"e_1_2_5_3_2","first-page":"198","article-title":"Primary angiosarcoma of the liver: review article","volume":"60","author":"Alrenga DP","year":"1975","journal-title":"Int Surg."},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19920101)69:1<52::AID-CNCR2820690111>3.0.CO;2-L"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197807)42:1<336::AID-CNCR2820420151>3.0.CO;2-V"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(78)80054-9"},{"key":"e_1_2_5_7_2","first-page":"649","article-title":"Primary leiomyosarcoma of the liver mimicking liver abscess","volume":"90","author":"Gates LK","year":"1995","journal-title":"AJG."},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(84)80145-8"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19990201)85:3<562::AID-CNCR7>3.0.CO;2-T"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197508)36:2<446::AID-CNCR2820360220>3.0.CO;2-7"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.1987.tb02647.x"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1827.1998.tb03897.x"},{"key":"e_1_2_5_13_2","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.5858\/2005-129-1480-HFDCSW","article-title":"Hepatic follicular dendritic cell sarcoma without Epstein\u2010Barr virus expression","volume":"129","author":"Torres U","year":"2005","journal-title":"Arch Pathol Lab Med."},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19870201)59:3<396::AID-CNCR2820590307>3.0.CO;2-W"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00383-004-1187-6"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199501053320104"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1997.15.2.646"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1996.14.5.1679"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-200203000-00015"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.02.026"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2002.20.3.791"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-200110000-00013"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2004.01.004"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2168.2000.01564.x"},{"key":"e_1_2_5_25_2","first-page":"319","article-title":"Primary sarcoma of the liver in the adult. 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