{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T11:58:27Z","timestamp":1773316707626,"version":"3.50.1"},"reference-count":45,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2007,3,9]],"date-time":"2007-03-09T00:00:00Z","timestamp":1173398400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2007,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND.<\/jats:title><jats:p>Prophylactic salpingo\u2010oophorectomy (SO), which is recommended in <jats:italic>BRCA1\/2<\/jats:italic> mutation carriers, still needs to be reappraised.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS.<\/jats:title><jats:p>In all, 89 <jats:italic>BRCA1\/BRCA2<\/jats:italic> mutation carriers underwent SO between 1994\u20132004. Past medical and familial history, SO, results and survival after SO were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS.<\/jats:title><jats:p>The series consisted of 56 <jats:italic>BRCA1<\/jats:italic> and 33 <jats:italic>BRCA2<\/jats:italic> mutation carriers. All but 1 had a family history of breast (BC) and\/or ovarian cancer; 42 <jats:italic>BRCA1<\/jats:italic> and 31 <jats:italic>BRCA2<\/jats:italic> had a personal history of BC. The median age at SO was 44 (<jats:italic>BRCA1<\/jats:italic>) and 49.5 (<jats:italic>BRCA2<\/jats:italic>) years for women without previous BC (not significant) and 48 (<jats:italic>BRCA1<\/jats:italic>) and 53 <jats:italic>BRCA2<\/jats:italic>) years (<jats:italic>P<\/jats:italic> = .03) for women with previous BC. Occult ovarian (n = 2) and\/or fallopian (n = 3) carcinomas were found in 4 patients (4.5%): 1 experienced recurrence (4 years), 2 are disease\u2010free (26 and 38 months of follow\u2010up), and 1 died from BC (12 months). Among the other 69 patients with previous BC (median follow\u2010up, 42 months), 14 developed ipsilateral or contralateral BC and 8 developed metastatic disease. Among the 16 patients without previous BC (median follow\u2010up, 27 months), 3 developed BC. Of the 89 patients, 85 are still alive: 3 died from BC and 1 died from pancreatic cancer. No peritoneal malignancy was observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS.<\/jats:title><jats:p>This study shows that prophylactic SO remains an important option for <jats:italic>BRCA1\/2<\/jats:italic> mutation carriers as asymptomatic ovarian\/fallopian cancers were found in 4.5% of patients. However, a longer follow\u2010up and larger series are required to more precisely evaluate the benefits of this procedure in terms of BC incidence, peritoneal malignancy, or recurrence. Cancer 2007. \u00a9 2007 American Cancer Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.22603","type":"journal-article","created":{"date-parts":[[2007,3,9]],"date-time":"2007-03-09T19:05:31Z","timestamp":1173467131000},"page":"1784-1790","source":"Crossref","is-referenced-by-count":44,"title":["Prophylactic salpingo\u2010oophorectomy in a series of 89 women carrying a <i>BRCA1<\/i> or a <i>BRCA2<\/i> mutation"],"prefix":"10.1002","volume":"109","author":[{"given":"Fatima","family":"Laki","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Youlia M.","family":"Kirova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pascale","family":"This","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"for the IC\u2010BOCRSG","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Corinne","family":"Plancher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernard","family":"Asselain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xavier","family":"Sastre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominique","family":"Stoppa\u2010Lyonnet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Remy","family":"Salmon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,4,18]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)10109-4"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/91.15.1310"},{"key":"e_1_2_6_4_2","first-page":"678","article-title":"Genetic linkage analysis in familial breast and ovarian cancer: results from 214 families. 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