{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T23:34:51Z","timestamp":1782516891328,"version":"3.54.5"},"reference-count":37,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2007,3,26]],"date-time":"2007-03-26T00:00:00Z","timestamp":1174867200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2007,5,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Cutaneous metastases from well\u2010differentiated thyroid carcinomas are rare and are usually identified in patients with widely disseminated disease. Occasionally, thyroid carcinomas can present as cutaneous metastases for which the primary site needs to be determined. Papillary thyroid carcinomas (PTCs) commonly have <jats:italic>BRAF<jats:sup>V600E<\/jats:sup><\/jats:italic> mutation. A series of 16 cutaneous metastases were analyzed from well\u2010differentiated thyroid carcinomas to learn more about the clinicopathologic features and <jats:italic>BRAF<jats:sup>V600E<\/jats:sup><\/jats:italic> mutation status.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Eleven cases of PTC and 5 of follicular thyroid carcinoma (FTC) metastatic to the skin were evaluated. All cutaneous metastases were studied histologically and with thyroglobulin and thyroid transcription factor immunostains. All tumor samples were analyzed for mutations at nucleotide 1799 in exon 15 of the <jats:italic>BRAF<\/jats:italic> gene.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Two patients with FTC presented with cutaneous metastases. Fourteen of 16 patients died of disease and 2 were alive with disease at follow\u2010up. The histologic features of the cutaneous metastases were generally characteristic of the primary tumor; however, 2 of the 11 PTC metastases demonstrated cytoplasmic clearing not typical of classic PTC. <jats:italic>BRAF<jats:sup>V600E<\/jats:sup><\/jats:italic> mutation (T1799A) was detected in 5 of 11 cases of PTC and in none of the 5 FTCs.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>Cutaneous metastases from PTC may show prominent clear cell change requiring differentiation from clear cell hidradenoma, clear cell dermatofibroma, malignant melanoma with prominent clear cell change, and cutaneous metastasis from renal cell carcinoma. <jats:italic>BRAF<jats:sup>V600E<\/jats:sup><\/jats:italic> mutation is identified in a subset of cutaneous metastases from PTC. Cutaneous metastases from PTC and FTC are associated with a very poor prognosis. Cancer 2007. \u00a9 2007 American Cancer Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.22641","type":"journal-article","created":{"date-parts":[[2007,3,26]],"date-time":"2007-03-26T15:53:56Z","timestamp":1174924436000},"page":"1965-1971","source":"Crossref","is-referenced-by-count":15,"title":["Clinicopathologic features and <i>BRAF<sup>V600E<\/sup><\/i> mutation analysis in cutaneous metastases from well\u2010differentiated thyroid carcinomas"],"prefix":"10.1002","volume":"109","author":[{"given":"Lori A.","family":"Erickson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuki","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alina G.","family":"Bridges","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Svetomir N.","family":"Markovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo V.","family":"Lloyd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,3,26]]},"reference":[{"key":"e_1_2_5_2_2","first-page":"57","volume-title":"World Health Organization Classification of Tumours Pathology & Genetics of Tumours of Endocrine Organs","author":"LiVolsi VA","year":"2004"},{"key":"e_1_2_5_3_2","first-page":"67","volume-title":"World Health Organization Classification of Tumours Pathology & Genetics of Tumours of Endocrine Organs","author":"Sobrinho Simoes M","year":"2004"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(97)70239-1"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2003.012922"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF03349817"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.dad.0000164606.33779.6f"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003072-200205000-00021"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1089\/thy.1998.8.1045"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1159\/000247091"},{"key":"e_1_2_5_11_2","first-page":"532","article-title":"Thyroid carcinoma presenting as a solitary skin metastasis","volume":"31","author":"Pitlik S","year":"1983","journal-title":"Cutis."},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(84)80320-5"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1159\/000247702"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1159\/000248571"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(91)70216-O"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(08)80746-3"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1089\/thy.1993.3.235"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1370267"},{"key":"e_1_2_5_19_2","first-page":"241","article-title":"Distant metastases in papillary thyroid cancer: a review of 91 patients","volume":"177","author":"Hoie J","year":"1988","journal-title":"Cancer"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature00766"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0248-4900(01)01125-X"},{"key":"e_1_2_5_22_2","first-page":"101","article-title":"Control of the ERK MAP kinase cascade by Ras and Raf","volume":"27","author":"Marais R","year":"1996","journal-title":"Cancer Surv."},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/95.8.625"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1208822"},{"key":"e_1_2_5_25_2","first-page":"1454","article-title":"High prevalence of BRAF mutations in thyroid cancer: genetic evidence for constitutive activation of the RET\/PTC\u2010RAS\u2010BRAF signaling pathway in papillary thyroid carcinoma","volume":"63","author":"Kimura ET","year":"2003","journal-title":"Cancer Res."},{"key":"e_1_2_5_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.3700306"},{"key":"e_1_2_5_27_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-030838"},{"key":"e_1_2_5_28_2","first-page":"1729","article-title":"The BRAFT1796A transversion is a prevalent mutational event in human thyroid microcarcinoma","volume":"6","author":"Sedliarou I","year":"2004","journal-title":"Int J Oncol."},{"key":"e_1_2_5_29_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-005-1236-0"},{"key":"e_1_2_5_30_2","first-page":"4561","article-title":"High prevalence of BRAF gene mutation in papillary thyroid carcinomas and thyroid tumor cell lines","volume":"63","author":"Xu X","year":"2003","journal-title":"Cancer Res."},{"key":"e_1_2_5_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)63902-8"},{"key":"e_1_2_5_32_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-198510000-00002"},{"key":"e_1_2_5_33_2","doi-asserted-by":"publisher","DOI":"10.5858\/2005-129-e113-CCHAMO"},{"key":"e_1_2_5_34_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199604000-00013"},{"key":"e_1_2_5_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(90)70002-Y"},{"key":"e_1_2_5_36_2","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3800198"},{"key":"e_1_2_5_37_2","doi-asserted-by":"publisher","DOI":"10.1385\/EP:16:2:099"},{"key":"e_1_2_5_38_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2005-0987"}],"container-title":["Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcncr.22641","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cncr.22641","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T12:18:07Z","timestamp":1760271487000},"score":1,"resource":{"primary":{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/10.1002\/cncr.22641"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,3,26]]},"references-count":37,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2007,5,15]]}},"alternative-id":["10.1002\/cncr.22641"],"URL":"https:\/\/doi.org\/10.1002\/cncr.22641","archive":["Portico"],"relation":{},"ISSN":["0008-543X","1097-0142"],"issn-type":[{"value":"0008-543X","type":"print"},{"value":"1097-0142","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,3,26]]}}}