{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T21:19:08Z","timestamp":1791235148902,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2007,4,4]],"date-time":"2007-04-04T00:00:00Z","timestamp":1175644800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2007,5,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Inherited genetic predispositions are important risk factors for the development of cancer in general. To determine genetic susceptibility for 14 common cancers, a case\u2013control study of the impact of a family history of cancer in first\u2010degree relatives was conducted. The authors further evaluated the effect modification by habitual smoking with adjustment for other confounding environmental factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>In total, 18,836 cancer cases and 28,125 age\u2013matched and sex\u2013matched controls, confirmed as being free of cancer, were recruited. Odds ratios (ORs) and 95% confidence intervals were determined by multiple logistic regression analysis, including stratification by family history for 14 cancer sites and interactions with a smoking history.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>The associations between family history and risk of cancer were generally stronger at the same sites than across cancer sites. Risks to first\u2010degree relatives at the same sites were found to be significantly elevated with 8 of 14 cancer sites; especially high ORs were found for prostate and thyroid cancers. Some across\u2010site associations were observed; in particular, a reciprocal association between breast and prostate cancer was found. The interaction between family history and smoking history for breast cancer was found to be statistically significant. There was no statistical evidence for the interactions in other sites, but among subjects with a family history, the ORs were found to be higher in smokers compared with nonsmokers.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>The results of the current study support the hypothesis of a genetic susceptibility to cancers in family members. For breast cancer, the interaction between family history and smoking history was observed to be significant. Cancer 2007. \u00a9 2007 American Cancer Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.22685","type":"journal-article","created":{"date-parts":[[2007,4,4]],"date-time":"2007-04-04T11:22:34Z","timestamp":1175685754000},"page":"2116-2123","source":"Crossref","is-referenced-by-count":29,"title":["Effect of familial history and smoking on common cancer risks in Japan"],"prefix":"10.1002","volume":"109","author":[{"given":"Takeshi","family":"Suzuki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keitaro","family":"Matsuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Wakai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akio","family":"Hiraki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaoru","family":"Hirose","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeki","family":"Sato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryuzo","family":"Ueda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuo","family":"Tajima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,4,4]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/86.21.1600"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a009833"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0215(200102)9999:9999<::AID-IJC1147>3.0.CO;2-C"},{"key":"e_1_2_6_5_2","first-page":"35","article-title":"A model of practical cancer prevention for out\u2010patients visiting a hospital: the Hospital\u2010based Epidemiologic Research Program at Aichi Cancer Center (HERPACC)","volume":"1","author":"Tajima K","year":"2000","journal-title":"Asian Pac J Cancer Prev."},{"key":"e_1_2_6_6_2","first-page":"99","article-title":"Gene\u2010environment interactions and polymorphism studies of cancer risk in the Hospital\u2010based Epidemiologic Research Program at Aichi Cancer Center II (HERPACC\u2010II)","volume":"2","author":"Hamajima N","year":"2001","journal-title":"Asian Pac J Cancer Prev."},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyg062"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00051676"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-4356(96)00297-1"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(01)06524-2"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19990331)81:1<12::AID-IJC3>3.0.CO;2-0"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.305.6858.855"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/86.24.1860"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19930701)72:1<114::AID-CNCR2820720122>3.0.CO;2-0"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(94)91578-4"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199705153362001"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s001090050162"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.13.5950"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng0597-17"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1054\/bjoc.2000.1585"},{"key":"e_1_2_6_21_2","first-page":"399","article-title":"Cigarette smoking and breast cancer","volume":"5","author":"Baron JA","year":"1996","journal-title":"Cancer Epidemiol Biomarkers Prev."},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1097\/00008469-199606000-00003"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2003.tb01418.x"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/90.10.761"},{"key":"e_1_2_6_25_2","first-page":"327","article-title":"Cigarette smoking increases risk for breast cancer in high\u2010risk breast cancer families","volume":"10","author":"Couch FJ","year":"2001","journal-title":"Cancer Epidemiol Biomarkers Prev."},{"key":"e_1_2_6_26_2","first-page":"3","article-title":"Genetic polymorphism of CYP genes, alone or in combination, as a risk modifier of tobacco\u2010related cancers","volume":"9","author":"Bartsch H","year":"2000","journal-title":"Cancer Epidemiol Biomarkers Prev."},{"issue":"148","key":"e_1_2_6_27_2","first-page":"231","article-title":"The glutathione S\u2010transferases: influence of polymorphism on cancer susceptibility","author":"Strange RC","year":"1999","journal-title":"IARC Sci Publ."},{"key":"e_1_2_6_28_2","first-page":"29","article-title":"Molecular genetics and epidemiology of the NAT1 and NAT2 acetylation polymorphisms","volume":"9","author":"Hein DW","year":"2000","journal-title":"Cancer Epidemiol Biomarkers Prev."},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.epirev.a000776"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19990301)80:5<699::AID-IJC12>3.0.CO;2-7"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1026349702909"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/hyl025"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djj005"},{"key":"e_1_2_6_34_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a009259"},{"key":"e_1_2_6_35_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/dji338"},{"key":"e_1_2_6_36_2","doi-asserted-by":"publisher","DOI":"10.2188\/jea.5.99"}],"container-title":["Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcncr.22685","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cncr.22685","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T12:18:20Z","timestamp":1760271500000},"score":1,"resource":{"primary":{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/10.1002\/cncr.22685"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,4,4]]},"references-count":35,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2007,5,15]]}},"alternative-id":["10.1002\/cncr.22685"],"URL":"https:\/\/doi.org\/10.1002\/cncr.22685","archive":["Portico"],"relation":{},"ISSN":["0008-543X","1097-0142"],"issn-type":[{"value":"0008-543X","type":"print"},{"value":"1097-0142","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,4,4]]}}}